Westerman R A, Widdop R E, Hogan C, Zimmet P
Department of Physiology, Monash University, Clayton, Vic., Australia.
Neurosci Lett. 1987 Oct 16;81(1-2):177-82. doi: 10.1016/0304-3940(87)90361-2.
Painful transcutaneous electrical nerve stimulation (TENS) of the foot dorsum evoked axon reflex vasodilatation, measured by laser Doppler flowmetry. In addition, acetylcholine (ACh) and sodium nitrite (NaNO2) were iontophoresed to cause vasodilatation by endothelium dependent and independent mechanisms, respectively. Compared with healthy volunteers, diabetic patients with clinically diagnosed neuropathy showed reduced electrical axon reflex flare and ACh responses, but not NaNO2 responses. Such reduced cutaneous nocifensor functions may contribute to some symptoms and complications of diabetes mellitus.
通过激光多普勒血流仪测量发现，足背的经皮电刺激神经疗法（TENS）引发的疼痛会诱发轴突反射性血管舒张。此外，分别通过内皮依赖性和非依赖性机制，离子导入乙酰胆碱（ACh）和亚硝酸钠（NaNO2）来引起血管舒张。与健康志愿者相比，临床诊断为神经病变的糖尿病患者的电轴突反射性红晕和ACh反应减弱，但NaNO2反应未减弱。这种皮肤伤害感受功能的降低可能会导致糖尿病的一些症状和并发症。
