School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia.
School of Medicine & Public Health, The University of Newcastle, Newcastle, NSW 2308, Australia.
Future Med Chem. 2018 Apr 1;10(8):839-844. doi: 10.4155/fmc-2017-0245. Epub 2018 Apr 5.
Several vesicular systems loaded with curcumin have found their way in the therapeutic applications of several diseases, primarily acting through their immunological pathways. Such systems use particles at a nanoscale range, bringing about their intended use through a range of complex mechanisms. Apart from delivering drug substances into target tissues, these vesicular systems also effectively overcome problems like insolubility and unequal drug distribution. Several mechanisms are explored lately by different workers, and interest over vesicular curcumin has been renewed in the past decade. This commentary discusses several immunological targets in which curcumin is employed in a vesicular form.
几种载有姜黄素的囊泡系统已经在几种疾病的治疗应用中找到了出路，主要通过其免疫途径发挥作用。这些系统使用纳米级的颗粒，通过一系列复杂的机制来实现其预期的用途。除了将药物输送到靶组织外，这些囊泡系统还能有效地克服溶解度和药物分布不均等问题。最近，不同的研究人员探索了几种机制，过去十年中，对囊泡姜黄素的兴趣又重新燃起。本评论讨论了几种姜黄素以囊泡形式作用的免疫靶点。
