School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Division of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, OH, USA.
Int J Nanomedicine. 2020 May 1;15:3099-3120. doi: 10.2147/IJN.S210320. eCollection 2020.
Curcumin, a yellow-colored polyphenol extracted from the rhizome of turmeric root, is commonly used as a spice and nutritional supplement. It exhibits many pharmacological activities such as anti-inflammatory, anti-bacterial, anti-cancer, anti-Alzheimer, and anti-fungal. However, the therapeutic application of curcumin is limited by its extremely low solubility in aqueous buffer, instability in body fluids, and rapid metabolism. Nano delivery system has shown excellent potential to improve the solubility, biocompatibility and therapeutic effect of curcumin. In this review, we focus on the recent development of nano encapsulated curcumin and its potential for biomedical applications.
姜黄素是一种从姜黄根茎中提取的黄色多酚类化合物,通常用作香料和营养补充剂。它具有许多药理活性,如抗炎、抗菌、抗癌、抗老年痴呆症和抗真菌。然而,姜黄素的治疗应用受到其在水缓冲液中极低的溶解度、体液中的不稳定性和快速代谢的限制。纳米递药系统已显示出改善姜黄素的溶解度、生物相容性和治疗效果的巨大潜力。在这篇综述中,我们重点介绍了纳米封装姜黄素的最新发展及其在生物医学中的应用潜力。