自发性高血压大鼠（SHR）及相关正常血压大鼠（WKY）的红细胞钠代谢与肾钠排泄
Erythrocyte sodium metabolism and renal sodium excretion in spontaneously hypertensive rats (SHR) and related normotensive rats (WKY).
作者信息
Gross V, Gnüchtel U, Kreher C
机构信息
Central Institute of Cardiovascular Research, Academy of Sciences, Berlin-Buch, G.D.R.
出版信息
Physiol Bohemoslov. 1987;36(5):477-80.
SHR being in osmotic diuresis responded to an intravenous saline load with greater sodium excretion than WKY. Volume expansion and sodium loading did not affect the erythrocyte sodium content. Both in the non-infused and in the infused sodium-loaded state SHR had a greater Na-Li-exchange rate than WKY. In the SHR the net-22Na-gain(Ery) was not influenced by the sodium loading procedure. In WKY infusion and sodium loading induced a faster erythrocyte 22Na-uptake and a lower ouabain effect on the net-22Na-gain. The sodium metabolism differences in SHR and WKY could be due to cell membrane differences or different hormonal responses to volume and sodium loading and may be important for the sodium excretion pattern in SHR and WKY.
处于渗透性利尿状态的自发性高血压大鼠（SHR）对静脉输注生理盐水的反应是钠排泄量比正常血压Wistar-Kyoto大鼠（WKY）更多。容量扩张和钠负荷并未影响红细胞钠含量。在未输注和输注钠负荷状态下，SHR的钠-锂交换率均高于WKY。在SHR中，净22Na摄取量（红细胞）不受钠负荷过程的影响。在WKY中，输注和钠负荷导致红细胞对22Na的摄取更快，哇巴因对净22Na摄取量的影响更低。SHR和WKY在钠代谢方面的差异可能是由于细胞膜差异或对容量和钠负荷的激素反应不同，这可能对SHR和WKY的钠排泄模式很重要。
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