Pokudin N I, Orlov S N, Postnov Iu V
Biull Eksp Biol Med. 1987 Oct;104(10):416-8.
The dependence of the rate of valinomycin-induced Na+/H+ erythrocyte metabolism on the extracellular K+ concentration has been investigated. It has been established that Na+/H+ metabolism in the erythrocytes of spontaneously hypertensive rats (SHR) is induced at higher [K+]o concentrations than in normotensive controls (WKY). The distinctions in the maximum rate of Na+/H+ metabolism were revealed only in SHR in pre-hypertensive stage (it was 20% lower than in WKY). It is suggested that the distinctions are determined by peculiarities of membrane cytoskeleton formation. The conclusion was confirmed in experiments on erythrocyte stability to orthovanadate effect.
研究了缬氨霉素诱导的红细胞钠/氢代谢速率对细胞外钾离子浓度的依赖性。已确定，自发性高血压大鼠（SHR）红细胞中的钠/氢代谢在高于正常血压对照（WKY）的[K⁺]ₒ浓度下被诱导。仅在高血压前期的SHR中发现了钠/氢代谢最大速率的差异（比WKY低20%）。提示这些差异是由膜细胞骨架形成的特殊性决定的。在红细胞对原钒酸盐作用稳定性的实验中证实了这一结论。
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