Bezdrobnaia L K, Chernichenko V A, Red'ko N A
Radiobiologiia. 1987 Nov-Dec;27(6):728-32.
Nicotinamide and arabinoside cytosine mixed with hydroxyurea were shown to influence the relative amount of double-stranded DNA in Ehrlich ascites tumor cells in vitro subjected to single irradiation (10-30-52 Gy) and in Guerin's carcinoma in rat lungs exposed to fractionated 6 MeV neutron-radiation (1.25 Gy X 4). The DMF values for Ehrlich ascites tumor were a function of a dose range and the duration of the drugs' effect. Guerin's carcinoma DNA was found to be affected more readily when treated with radiation and drugs than when exposed to neutron radiation alone.
已表明，烟酰胺、阿糖胞苷与羟基脲混合使用时，在体外对经单次照射（10 - 30 - 52戈瑞）的艾氏腹水瘤细胞以及暴露于分次6兆电子伏中子辐射（1.25戈瑞×4）的大鼠肺部格林氏癌中双链DNA的相对量有影响。艾氏腹水瘤的剂量修正因子（DMF）值是剂量范围和药物作用持续时间的函数。研究发现，与仅接受中子辐射相比，格林氏癌的DNA在用辐射和药物治疗时更容易受到影响。
