Engel Lisa, Beaton Dorcas E, Touma Zahi
Toronto Western Hospital/University Health Network, 399 Bathurst Street, Room 1E-412, Toronto, Ontario M5T 2S8, Canada.
Institute of Health Policy, Management & Evaluation, University of Toronto; Health Sciences Building, 155 College Street, Suite 425, Toronto, Ontario M5T 3M6, Canada; Institute for Work & Health, 481 University Avenue, Suite 800, Toronto, Ontario M5G 2E9, Canada.
Rheum Dis Clin North Am. 2018 May;44(2):177-188. doi: 10.1016/j.rdc.2018.01.011. Epub 2018 Feb 21.
Clinicians, researchers, and outcome stakeholders have the crucial, albeit difficult, task of quantifying when a person or group experiences important change or difference on any given outcome measure, often in response to a specific intervention. The minimal clinically important difference (MCID) provides this quantified value of change/difference for a measure. There are many methods for MCID derivation, which can result in multiple values for the same measure. Thus, it is important for potential users of MCID values to be aware of the nuances of MCID development and cautions for interpreting values. This review outlines MCID-related definitions, methods, and guidelines.
临床医生、研究人员和结果利益相关者面临一项至关重要却又颇具难度的任务，即量化一个人或群体在任何给定的结果指标上何时经历了重要变化或差异，这通常是对特定干预措施的反应。最小临床重要差异（MCID）为一项指标提供了这种变化/差异的量化值。有许多推导MCID的方法，这可能导致同一指标有多个值。因此，MCID值的潜在使用者了解MCID制定的细微差别以及解释这些值时的注意事项非常重要。本综述概述了与MCID相关的定义、方法和指南。
