随机试验、荟萃分析和系统评价：以风湿病学为例

Randomized Trials, Meta-Analyses, and Systematic Reviews: Using Examples from Rheumatology.

作者信息

Pope Janet E, Hazlewood Glen S

机构信息

Rheumatology, University of Western Ontario, St. Joseph's Health Care, D2, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada.

Department of Medicine, University of Calgary, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada; Department of Community Health Sciences, University of Calgary, 1820 Richmond Road SW, Calgary, Alberta T2T 5C7, Canada.

出版信息

Rheum Dis Clin North Am. 2018 May;44(2):295-305. doi: 10.1016/j.rdc.2018.01.006.

DOI:10.1016/j.rdc.2018.01.006

PMID:29622296

Abstract

This article introduces contemporary ideas and standards for clinical research in rheumatology for randomized trials, systematic reviews, and meta-analyses. Examples of different randomized trials in rheumatic diseases are provided to understand the methods for trials and the rationale for outcomes within trials. Insights from meta-analyses and systematic literature reviews, including network meta-analyses within rheumatology treatment, are provided. Ethical considerations, sample size calculations, and types of randomized controlled trials are discussed.

摘要

本文介绍了风湿病临床研究中关于随机试验、系统评价和荟萃分析的当代理念与标准。文中提供了不同风湿性疾病随机试验的实例，以了解试验方法及试验中结果的理论依据。还提供了荟萃分析和系统文献综述的见解，包括风湿病治疗中的网状荟萃分析。讨论了伦理考量、样本量计算以及随机对照试验的类型。