Department of Haematology, Worcestershire Royal Hospital, Worcester, United Kingdom.
Blood. 2010 Oct 28;116(17):3140-6. doi: 10.1182/blood-2010-05-280883. Epub 2010 Jul 23.
Systematic reviews and meta-analyses are being increasingly used to summarize medical literature and identify areas in which research is needed. Systematic reviews limit bias with the use of a reproducible scientific process to search the literature and evaluate the quality of the individual studies. If possible the results are statistically combined into a meta-analysis in which the data are weighted and pooled to produce an estimate of effect. This article aims to provide the reader with a practical overview of systematic review and meta-analysis methodology, with a focus on the process of performing a review and the related issues at each step.
系统评价和荟萃分析越来越多地被用于总结医学文献，并确定需要研究的领域。系统评价通过使用可重复的科学过程来搜索文献和评估单个研究的质量，从而限制了偏倚。如果可能的话，将结果进行统计学合并为荟萃分析，其中对数据进行加权和汇总，以得出效应的估计值。本文旨在为读者提供系统评价和荟萃分析方法的实用概述，重点介绍进行审查的过程以及每个步骤的相关问题。
