Introduction to the Thematic Minireview Series: Redox metabolism and signaling.

In this sequel to the thematic collection of Minireviews on redox metabolism and signaling published last year, five articles plumb the redox metabolic pathways relevant to cell proliferation, stress response, and survival post-detachment from the extracellular matrix. The sixth article provides unexpected insights into the hepatic NAD(P)ome, revealing that more than half of these proteins reside outside the cytoplasmic and mitochondrial compartments, pointing to the paucity of knowledge on their functions. Collectively, these articles highlight the metabolic adaptability of proliferating cells to meet redox needs, the use of lipids to mediate mitochondrial stress responses, and the need for tools to interrogate compartment-specific pool sizes and oxidized/reduced ratios of antioxidants and lipids involved in redox homeostasis.