• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Regulation of redox balance in cancer and T cells.癌症和 T 细胞中氧化还原平衡的调节。
J Biol Chem. 2018 May 18;293(20):7499-7507. doi: 10.1074/jbc.TM117.000257. Epub 2017 Dec 27.
2
Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function.活性氧物种和线粒体动态平衡作为干细胞命运和功能的调节因子。
Antioxid Redox Signal. 2018 Jul 10;29(2):149-168. doi: 10.1089/ars.2017.7273. Epub 2017 Oct 26.
3
Subcellular Redox Signaling.亚细胞氧化还原信号传导
Adv Exp Med Biol. 2017;967:385-398. doi: 10.1007/978-3-319-63245-2_25.
4
The redox regulation of thiol dependent signaling pathways in cancer.癌症中硫醇依赖性信号通路的氧化还原调节
Curr Pharm Des. 2006;12(34):4427-43. doi: 10.2174/138161206779010549.
5
ROS signalling in the biology of cancer.ROS 信号在癌症生物学中的作用。
Semin Cell Dev Biol. 2018 Aug;80:50-64. doi: 10.1016/j.semcdb.2017.05.023. Epub 2017 Jun 3.
6
Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis.miRNAs 调控 Nrf2 抗氧化通路：氧化还原平衡调控中的新角色
Free Radic Biol Med. 2013 Sep;64:4-11. doi: 10.1016/j.freeradbiomed.2013.07.025. Epub 2013 Jul 21.
7
Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species.抗氧化剂通过清除活性氧维持细胞氧化还原稳态。
Cell Physiol Biochem. 2017;44(2):532-553. doi: 10.1159/000485089. Epub 2017 Nov 17.
8
Redox control of the survival of healthy and diseased cells.氧化还原控制健康细胞和病变细胞的存活。
Antioxid Redox Signal. 2011 Dec 1;15(11):2867-908. doi: 10.1089/ars.2010.3685. Epub 2011 Jun 11.
9
Targeting Metabolic-Redox Circuits for Cancer Therapy.靶向代谢-氧化还原通路治疗癌症。
Trends Biochem Sci. 2019 May;44(5):401-414. doi: 10.1016/j.tibs.2019.01.001. Epub 2019 Jan 21.
10
Therapy-induced senescence through the redox lens.通过氧化还原的视角看治疗诱导的衰老。
Redox Biol. 2024 Aug;74:103228. doi: 10.1016/j.redox.2024.103228. Epub 2024 Jun 6.

引用本文的文献

1
Hemocyanin controls levels in hemolymph by modulating intracellular ROS via p38 MAPK.血蓝蛋白通过p38丝裂原活化蛋白激酶调节细胞内活性氧来控制血淋巴中的水平。
Virulence. 2025 Dec;16(1):2546066. doi: 10.1080/21505594.2025.2546066. Epub 2025 Aug 25.
2
Metal-modulated T cell antitumor immunity and emerging metalloimmunotherapy.金属调节的T细胞抗肿瘤免疫与新兴的金属免疫疗法
Cancer Metastasis Rev. 2025 Apr 29;44(2):49. doi: 10.1007/s10555-025-10266-2.
3
The rewired immune microenvironment in leukemia.白血病中重新布线的免疫微环境。
Nat Immunol. 2025 Mar;26(3):351-365. doi: 10.1038/s41590-025-02096-9. Epub 2025 Feb 28.
4
A hybrid machine learning framework for functional annotation of mitochondrial glutathione transport and metabolism proteins in cancers.一种用于癌症中线粒体谷胱甘肽转运和代谢蛋白功能注释的混合机器学习框架。
BMC Bioinformatics. 2025 Feb 11;26(1):48. doi: 10.1186/s12859-025-06051-1.
5
Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer.针对癌症中CD8 T细胞和自然杀伤细胞的代谢功能障碍
Nat Rev Drug Discov. 2025 Mar;24(3):190-208. doi: 10.1038/s41573-024-01098-w. Epub 2024 Dec 12.
6
Stress response regulation of mRNA translation: Implications for antioxidant enzyme expression in cancer.mRNA 翻译调控应激反应：对癌症抗氧化酶表达的影响。
Proc Natl Acad Sci U S A. 2024 Nov 12;121(46):e2317846121. doi: 10.1073/pnas.2317846121. Epub 2024 Nov 4.
7
The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapy.线粒体在肿瘤转移中的作用及线粒体靶向癌症治疗的进展。
Cancer Metastasis Rev. 2024 Dec;43(4):1419-1443. doi: 10.1007/s10555-024-10211-9. Epub 2024 Sep 23.
8
Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.两亲性大分子纳米组装体中刺激响应性的结构决定因素
Prog Polym Sci. 2024 Jan;148. doi: 10.1016/j.progpolymsci.2023.101765. Epub 2023 Dec 9.
9
Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature.N-乙酰半胱氨酸对顺铂毒性的影响：文献综述
Biologics. 2024 Jan 16;18:7-19. doi: 10.2147/BTT.S438150. eCollection 2024.
10
The role of ROS in tumor infiltrating immune cells and cancer immunotherapy.活性氧簇在肿瘤浸润免疫细胞和癌症免疫治疗中的作用。
Metabolism. 2024 Feb;151:155747. doi: 10.1016/j.metabol.2023.155747. Epub 2023 Nov 30.

本文引用的文献

1
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.耐药物持久性癌细胞易受谷胱甘肽过氧化物酶4（GPX4）抑制的影响。
Nature. 2017 Nov 9;551(7679):247-250. doi: 10.1038/nature24297. Epub 2017 Nov 1.
2
Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.化学蛋白质组学鉴定出基因定义癌症中的可药物化靶点。
Cell. 2017 Oct 19;171(3):696-709.e23. doi: 10.1016/j.cell.2017.08.051. Epub 2017 Sep 28.
3
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.癌细胞的治疗抗性状态对脂质过氧化酶途径的依赖性。
Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5.
4
Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation.在CD4+ T细胞活化过程中，活性氧对于驱动高效且持续的有氧糖酵解是必需的。
PLoS One. 2017 Apr 20;12(4):e0175549. doi: 10.1371/journal.pone.0175549. eCollection 2017.
5
Glutathione Primes T Cell Metabolism for Inflammation.谷胱甘肽激活 T 细胞代谢以缓解炎症。
Immunity. 2017 Apr 18;46(4):675-689. doi: 10.1016/j.immuni.2017.03.019.
6
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.用胱硫醚酶对L-胱氨酸进行全身消耗会增加活性氧并抑制肿瘤生长。
Nat Med. 2017 Jan;23(1):120-127. doi: 10.1038/nm.4232. Epub 2016 Nov 21.
7
Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.线粒体复合物I位点I处超氧化物-HO产生的抑制剂可预防干细胞增生和缺血再灌注损伤。
Cell Metab. 2016 Oct 11;24(4):582-592. doi: 10.1016/j.cmet.2016.08.012. Epub 2016 Sep 22.
8
RETRACTED: PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.撤回：PHGDH 表达对于线粒体氧化还原稳态、乳腺癌干细胞维持和肺转移是必需的。
Cancer Res. 2016 Aug 1;76(15):4430-42. doi: 10.1158/0008-5472.CAN-16-0530. Epub 2016 Jun 8.
9
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling.线粒体产生超氧化物和过氧化氢作为线粒体氧化还原信号的来源。
Free Radic Biol Med. 2016 Nov;100:14-31. doi: 10.1016/j.freeradbiomed.2016.04.001. Epub 2016 Apr 13.
10
Reductive carboxylation supports redox homeostasis during anchorage-independent growth.还原性羧化作用在非锚定依赖性生长过程中维持氧化还原稳态。
Nature. 2016 Apr 14;532(7598):255-8. doi: 10.1038/nature17393. Epub 2016 Apr 6.

癌症和 T 细胞中氧化还原平衡的调节。

Regulation of redox balance in cancer and T cells.

机构信息

From the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.

From the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611

出版信息

J Biol Chem. 2018 May 18;293(20):7499-7507. doi: 10.1074/jbc.TM117.000257. Epub 2017 Dec 27.

DOI:10.1074/jbc.TM117.000257
PMID:29282291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5961053/
Abstract

Reactive oxygen species (ROS) mediate redox signaling necessary for numerous cellular functions. Yet, high levels of ROS in cells and tissues can cause damage and cell death. Therefore, regulation of redox homeostasis is essential for ROS-dependent signaling that does not incur cellular damage. Cells achieve this optimal balance by coordinating ROS production and elimination. In this Minireview, we discuss the mechanisms by which proliferating cancer and T cells maintain a carefully controlled redox balance. Greater insight into such redox biology may enable precisely targeted manipulation of ROS for effective medical therapies against cancer or immunological disorders.

摘要

活性氧 (ROS) 介导的氧化还原信号对于许多细胞功能是必需的。然而，细胞和组织中高水平的 ROS 会导致损伤和细胞死亡。因此，对于不引起细胞损伤的 ROS 依赖性信号，氧化还原稳态的调节是必不可少的。细胞通过协调 ROS 的产生和消除来实现这种最佳平衡。在这篇简评中，我们讨论了增殖的癌症和 T 细胞维持精细控制的氧化还原平衡的机制。对这种氧化还原生物学的更深入了解可能使我们能够精确地操纵 ROS，从而为癌症或免疫性疾病的有效医学治疗提供靶向治疗。