癌症和 T 细胞中氧化还原平衡的调节。
Regulation of redox balance in cancer and T cells.
机构信息
From the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
From the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611
出版信息
J Biol Chem. 2018 May 18;293(20):7499-7507. doi: 10.1074/jbc.TM117.000257. Epub 2017 Dec 27.
Abstract
Reactive oxygen species (ROS) mediate redox signaling necessary for numerous cellular functions. Yet, high levels of ROS in cells and tissues can cause damage and cell death. Therefore, regulation of redox homeostasis is essential for ROS-dependent signaling that does not incur cellular damage. Cells achieve this optimal balance by coordinating ROS production and elimination. In this Minireview, we discuss the mechanisms by which proliferating cancer and T cells maintain a carefully controlled redox balance. Greater insight into such redox biology may enable precisely targeted manipulation of ROS for effective medical therapies against cancer or immunological disorders.
摘要
活性氧 (ROS) 介导的氧化还原信号对于许多细胞功能是必需的。然而，细胞和组织中高水平的 ROS 会导致损伤和细胞死亡。因此，对于不引起细胞损伤的 ROS 依赖性信号，氧化还原稳态的调节是必不可少的。细胞通过协调 ROS 的产生和消除来实现这种最佳平衡。在这篇简评中，我们讨论了增殖的癌症和 T 细胞维持精细控制的氧化还原平衡的机制。对这种氧化还原生物学的更深入了解可能使我们能够精确地操纵 ROS，从而为癌症或免疫性疾病的有效医学治疗提供靶向治疗。
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