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Management and Preventive Measures for Febrile Neutropenia.发热性中性粒细胞减少症的管理与预防措施
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Emergency department management of chemotherapy related febrile neutropenia: An opportunity to improve care.急诊科对化疗相关性发热性中性粒细胞减少症的管理:改善护理的机会。
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本文引用的文献

1
Application of the MASCC and CISNE Risk-Stratification Scores to Identify Low-Risk Febrile Neutropenic Patients in the Emergency Department.应用MASCC和CISNE风险分层评分识别急诊科低风险发热性中性粒细胞减少患者。
Ann Emerg Med. 2017 Jun;69(6):755-764. doi: 10.1016/j.annemergmed.2016.11.007. Epub 2016 Dec 29.
2
Management of febrile neutropaenia: ESMO Clinical Practice Guidelines.发热性中性粒细胞减少症的管理:ESMO临床实践指南
Ann Oncol. 2016 Sep;27(suppl 5):v111-v118. doi: 10.1093/annonc/mdw325.
3
Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia in a prospective cohort of patients from the FINITE study.疑似稳定发热性中性粒细胞减少症患者严重并发症的预测:来自 FINITE 研究前瞻性队列患者的临床稳定发热性中性粒细胞减少症指数的验证。
J Clin Oncol. 2015 Feb 10;33(5):465-71. doi: 10.1200/JCO.2014.57.2347. Epub 2015 Jan 5.
4
Risk and Consequences of Chemotherapy-Induced Febrile Neutropenia in Patients With Metastatic Solid Tumors.转移性实体瘤患者化疗所致发热性中性粒细胞减少的风险和后果。
J Oncol Pract. 2015 Jan;11(1):47-54. doi: 10.1200/JOP.2014.001492. Epub 2014 Dec 9.
5
Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the paradigm febrile mucositis.癌症中性粒细胞减少症患者的黏膜屏障损伤、发热和感染:引入发热性黏膜炎范例。
Br J Haematol. 2014 Nov;167(4):441-52. doi: 10.1111/bjh.13113. Epub 2014 Sep 6.
6
Management of febrile neutropenia in the era of bacterial resistance.细菌耐药时代的发热性中性粒细胞减少症管理
Ther Adv Infect Dis. 2013 Feb;1(1):37-43. doi: 10.1177/2049936113475610.
7
Distinct inflammatory mediator patterns characterize infectious and sterile systemic inflammation in febrile neutropenic hematology patients.发热性中性粒细胞减少症血液病患者的感染性和无菌性全身炎症具有不同的炎症介质特征。
PLoS One. 2014 Mar 18;9(3):e92319. doi: 10.1371/journal.pone.0092319. eCollection 2014.
8
Incidence, treatment, and consequences of chemotherapy-induced febrile neutropenia in the inpatient and outpatient settings.住院和门诊环境中化疗引起的发热性中性粒细胞减少症的发病率、治疗及后果。
J Oncol Pharm Pract. 2014 Jun;20(3):190-8. doi: 10.1177/1078155213492450. Epub 2013 Jul 2.
9
Colony-stimulating factors for febrile neutropenia during cancer therapy.癌症治疗期间发热性中性粒细胞减少症的集落刺激因子。
N Engl J Med. 2013 Mar 21;368(12):1131-9. doi: 10.1056/NEJMct1210890.
10
The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of use for identifying low-risk febrile neutropenic cancer patients.多国癌症支持治疗协会(MASCC)风险指数评分:用于识别低危发热性中性粒细胞减少症癌症患者的 10 年应用。
Support Care Cancer. 2013 May;21(5):1487-95. doi: 10.1007/s00520-013-1758-y. Epub 2013 Feb 27.

发热性中性粒细胞减少症的管理与预防措施

Management and Preventive Measures for Febrile Neutropenia.

作者信息

Lucas Austin J, Olin Jacqueline L, Coleman Megan D

出版信息

P T. 2018 Apr;43(4):228-232.

PMID:29622943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5871243/
Abstract

Febrile neutropenia (FN) is an oncological emergency and serious complication often resulting from chemotherapy. In patients with a weak or completely suppressed immune system, a fever may be the only sign of an underlying infection and immediate treatment is needed. Using risk evaluation scores, it is possible to stratify individual patient degree of risk. However, all patients warrant immediate antibiotic coverage. Antibiotic treatment of FN is broadened or narrowed based on individualized clinical scenarios. Prophylactic antimicrobials may be used in specific high-risk situations. This article briefly reviews FN, describes risk assessment tools, and discusses treatment and prophylactic options.

摘要

发热性中性粒细胞减少症(FN)是一种肿瘤急症和严重并发症,常由化疗引起。在免疫系统薄弱或完全受抑制的患者中,发热可能是潜在感染的唯一迹象,需要立即进行治疗。通过风险评估评分,可以对个体患者的风险程度进行分层。然而,所有患者都需要立即给予抗生素覆盖。FN的抗生素治疗会根据个体化临床情况进行调整,扩大或缩小用药范围。预防性抗菌药物可用于特定的高风险情况。本文简要回顾了FN,描述了风险评估工具,并讨论了治疗和预防方案。