Targeting microthrombosis and neuroinflammation with vepoloxamer for therapeutic neuroprotection after traumatic brain injury.
作者信息
Xiong Ye, Zhang Li, Zhang Zheng Gang, Mahmood Asim, Chopp Michael
机构信息
Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA.
Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
出版信息
Neural Regen Res. 2018 Mar;13(3):413-414. doi: 10.4103/1673-5374.228717.
Abstract
摘要
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本文引用的文献
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J Neurotrauma. 2018 Feb 15;35(4):661-670. doi: 10.1089/neu.2017.5284. Epub 2018 Jan 11.
2
Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation.内皮细胞衍生的血管性血友病因子是通过促进缺血后血栓炎症介导血管性血友病因子依赖性急性缺血性卒中的主要决定因素。
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1829-37. doi: 10.1161/ATVBAHA.116.307660. Epub 2016 Jul 21.
3
Poloxamer-188 and citicoline provide neuronal membrane integrity and protect membrane stability in cortical spreading depression.
Int J Neurosci. 2015;125(12):941-6. doi: 10.3109/00207454.2014.979289. Epub 2014 Dec 4.
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The pharmacokinetics and pharmacodynamics of Kollidon VA64 dissociate its protective effects from membrane resealing after controlled cortical impact in mice.Kollidon VA64 的药代动力学和药效学将其保护作用与其在小鼠控制性皮质撞击后的膜重封闭作用分离。
J Cereb Blood Flow Metab. 2014 Aug;34(8):1347-53. doi: 10.1038/jcbfm.2014.89. Epub 2014 May 14.
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Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.创伤性脑损伤导致血小板二磷酸腺苷和花生四烯酸受体抑制，与人类和大鼠的出血性休克无关。
J Trauma Acute Care Surg. 2014 May;76(5):1169-76. doi: 10.1097/TA.0000000000000216.
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Differential effects of commercial-grade and purified poloxamer 188 on renal function.商业级和纯化泊洛沙姆188对肾功能的不同影响。
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Poloxamer 188 protects neurons against ischemia/reperfusion injury through preserving integrity of cell membranes and blood brain barrier.泊洛沙姆 188 通过维持细胞膜和血脑屏障的完整性来保护神经元免受缺血/再灌注损伤。
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J Neuroinflammation. 2013 Feb 28;10:32. doi: 10.1186/1742-2094-10-32.
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Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications.泊洛沙姆188（p188）作为一种用于生物医学应用的细胞膜修复试剂。
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