Department of Polymer Materials, College of Materials Science and Engineering , Shanghai University , Materials Building Room 447, Nanchen Street 333 , Shanghai 200444 , China.
School of Engineering and Applied Sciences , Harvard University , 29 Oxford Street , Cambridge , Massachusetts 02138 , United States.
ACS Appl Mater Interfaces. 2018 Apr 25;10(16):13258-13263. doi: 10.1021/acsami.8b01514. Epub 2018 Apr 10.
The present work provides a versatile access for "smart" cyclodextrins (CDs) that are responsive to temperature, redox, and metal ions. These CDs are modified with oligoethylene glycols through thiol-ene click chemistry, which are inherently thermoresponsive in aqueous solutions. At the same time, their thermoresponsiveness is tunable through oxidation or metal ion chelation of thioether moieties. Significantly, these stimuli-responsive CDs retained strong inclusion abilities to guest dyes, and the inclusion complexation can be tuned by thermally induced phase transitions, oxidation, as well as metal chelation. The stimuli-responsive complexation with dyes allows to fabricate colorimetric/fluorescent sensors for temperature or for soft metal ions, such as Ag and Hg. With multiple responsiveness integrated in one material, these monodisperse CDs have formed a new class of stimuli-responsive macrocycles, which can reversibly encapsulate and release guest species through multiple switches.
本工作为对温度、氧化还原和金属离子有响应的“智能”环糊精（CDs）提供了一种通用的方法。这些 CDs 通过硫醇-烯点击化学反应与低聚乙二醇修饰，在水溶液中具有固有热敏性。同时，它们的热敏性可以通过硫醚部分的氧化或金属离子螯合来调节。重要的是，这些响应性 CD 仍然具有对客体染料的强包合能力，并且包合络合可以通过热诱导的相转变、氧化以及金属螯合来调节。与染料的响应性络合可以用于制备用于温度或用于软金属离子（如 Ag 和 Hg）的比色/荧光传感器。通过将多种响应性集成到一种材料中，这些单分散的 CDs 形成了一类新的刺激响应性大环，它们可以通过多个开关可逆地包封和释放客体物质。
