来自Cryptocarya laevigata 的次生代谢产物，含螺[3.5]壬烷的单萜聚酮。
Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.
机构信息
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences , Kanazawa University , Kanazawa , 920-1192 , Japan.
Tokyo University of Pharmacy and Life Sciences , Hachioji , Tokyo , 192-0392 , Japan.
出版信息
Org Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6.
Abstract
Six novel lactone derivatives, cryptolaevilactones A-F (1-6), were isolated from Cryptocarya laevigata. Their unique spiro[3.5]nonane moiety by hetero [2 + 2] cyclization with monoterpene and polyketide was found for the first time in nature. Structural elucidation using various nuclear magnetic resonance (NMR) techniques revealed that 1-3 and 4-6 are diastereomers and partially established the absolute configurations.
摘要
从Cryptocarya laevigata 中分离得到了 6 种新型内酯衍生物，cryptolaevilactones A-F（1-6）。通过单萜和聚酮的杂 [2 + 2] 环化反应，发现它们具有独特的螺[3.5]壬烷部分，这在自然界中还是首次发现。通过各种核磁共振（NMR）技术进行结构阐明表明，1-3 和 4-6 是非对映异构体，并且部分确定了绝对构型。
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