RNA聚合酶II延伸复合物的结构：对Spt4/5和Elf1的新见解。
Architecture of the RNA polymerase II elongation complex: new insights into Spt4/5 and Elf1.
作者信息
Ehara Haruhiko, Sekine Shun-Ichi
机构信息
a RIKEN Center for Life Science Technologies , 1-7-22 Suehiro-cho, Tsurumi-ku , Yokohama 230-0045 , Japan.
出版信息
Transcription. 2018;9(5):286-291. doi: 10.1080/21541264.2018.1454817. Epub 2018 May 7.
Abstract
Transcription by RNA polymerase II (Pol II) is accomplished with the aid of numerous accessory factors specific to each transcriptional stage. The structure of the Pol II elongation complex (EC) bound with Spt4/5, Elf1, and TFIIS unveiled the sophisticated basal EC architecture essential for transcription elongation and other transcription-related events.
摘要
RNA聚合酶II（Pol II）的转录是在众多特定于每个转录阶段的辅助因子的帮助下完成的。与Spt4/5、Elf1和TFIIS结合的Pol II延伸复合物（EC）的结构揭示了对转录延伸和其他转录相关事件至关重要的复杂基础EC结构。
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