Raad Micheal, Neuman Brian J, Jain Amit, Hassanzadeh Hamid, Passias Peter G, Klineberg Eric, Mundis Gregory M, Protopsaltis Themistocles S, Miller Emily K, Smith Justin S, Lafage Virginie, Hamilton D Kojo, Bess Shay, Kebaish Khaled M, Sciubba Daniel M
Departments of1Orthopaedic Surgery and.
2Orthopaedic Surgery and.
J Neurosurg Spine. 2018 Jul;29(1):68-74. doi: 10.3171/2017.10.SPINE17830. Epub 2018 Apr 6.
OBJECTIVE Given the recent shift in health care toward quality reporting requirements and a greater emphasis on a cost-quality approach, patient stratification with respect to long-term outcomes and the use of health care resources is of increasing value. Stratification tools may be effective if they are simple and evidence based. The authors hypothesize that preoperative patient-reported activity levels might independently predict postoperative outcomes in patients with adult spinal deformity. METHODS This is a retrospective cohort. A total of 575 patients in a prospective adult spinal deformity surgical database were identified with complete data regarding the preoperative level of activity. Answers to question 5 of the Scoliosis Research Society-22r Patient Questionnaire (SRS-22r) were used to stratify patients into active and inactive groups. Outcomes were length of hospital stay (LOS), level of activity, and reaching the minimum clinically important difference (MCID) for SRS-22r domains and the Physical Component Summary (PCS) of the SF-36 at 2 years postoperatively. The 2 groups were compared with respect to several potential confounders. Covariates with p < 0.1 were controlled for. The impact of activity on LOS was assessed using multivariate negative binomial regression analysis. Multivariate logistic regression models additionally controlling for the respective baseline health-related quality of life (HRQOL) scores were used to assess the association between preoperative activity levels and reaching the MCID at 2 years postoperatively. RESULTS A total of 420 (73%) of the 575 patients who met the inclusion criteria had complete data at 2 years postoperatively. The inactive group was more likely to be significantly older, have a higher Charlson Comorbidity Index, worse baseline radiographic deformity, and greater correction of most radiographic parameters. After controlling for possible confounders, the active group had a significantly shorter LOS (incidence risk ratio 0.91, p = 0.043). After adding respective baseline HRQOL scores to the models, active patients were significantly more likely to reach the MCID for the SRS-22r pain domain (OR 1.72, p = 0.026) and PCS (OR 1.94, p = 0.013). Active patients were also significantly more likely to be active at 2 years postoperatively on multivariate analysis (OR 8.94, p < 0.001). CONCLUSIONS The authors' results show that patients who belong to the inactive group are likely to have a longer LOS and lower odds of reaching the MCID in HRQOL or being active at 2 years postoperatively. Inquiring about patients' preoperative activity levels might be a reliable and simple stratification tool in terms of long- and short-term outcomes in ASD patients.
目的 鉴于近期医疗保健向质量报告要求转变,并更加强调成本-质量方法,根据长期预后和医疗资源使用情况对患者进行分层具有越来越重要的价值。如果分层工具简单且基于证据,可能会很有效。作者推测术前患者报告的活动水平可能独立预测成人脊柱畸形患者的术后预后。方法 这是一项回顾性队列研究。在前瞻性成人脊柱畸形手术数据库中,共识别出575例患者,其具有关于术前活动水平的完整数据。使用脊柱侧弯研究协会-22r患者问卷(SRS-22r)第5题的答案将患者分为活动组和不活动组。结局指标为住院时间(LOS)、活动水平,以及术后2年时SRS-22r各领域和SF-36身体成分总结(PCS)达到最小临床重要差异(MCID)的情况。对两组的几个潜在混杂因素进行了比较。对p<0.1的协变量进行了控制。使用多变量负二项回归分析评估活动对LOS的影响。多变量逻辑回归模型在进一步控制各自的基线健康相关生活质量(HRQOL)评分后,用于评估术前活动水平与术后2年达到MCID之间的关联。结果 在符合纳入标准的575例患者中,共有420例(73%)在术后2年有完整数据。不活动组患者年龄可能显著更大,Charlson合并症指数更高,基线影像学畸形更严重,大多数影像学参数的矫正程度更大。在控制了可能的混杂因素后,活动组的LOS显著更短(发病风险比0.91,p = 0.043)。在模型中加入各自的基线HRQOL评分后,活动组患者在术后2年更有可能达到SRS-22r疼痛领域(优势比1.72,p = 0.026)和PCS(优势比1.94,p = 0.013)的MCID。在多变量分析中,活动组患者在术后2年也显著更有可能保持活动状态(优势比8.94,p<0.001)。结论 作者的结果表明,属于不活动组的患者可能住院时间更长,在HRQOL方面达到MCID或术后2年保持活动状态的几率更低。询问患者术前活动水平可能是一种在成人脊柱畸形患者的短期和长期预后方面可靠且简单的分层工具。