尿胰蛋白酶抑制剂的三硝基苯基衍生物：一种强效抗纤溶药物。
Trinitrophenyl-derivative of urinary trypsin inhibitor: a strong antifibrinolytic agent.
作者信息
Sumi H, Hamada H, Maehara S, Yoshida E, Tsushima H, Maruyama M, Mihara H
机构信息
Department of Physiology, Miyazaki Medical College, Japan.
出版信息
Acta Haematol. 1987;78(4):225-8. doi: 10.1159/000205882.
PMID:2962413
Abstract
A trinitrophenyl derivative of urinary trypsin inhibitor (TNP-UTI) was found to demonstrate approximately 50 times stronger antiplasmin fibrinolysis than the intact UTI. Almost no change in antitrypsin or antichymotrypsin activity occurred as a result of the UTI modification. TNP-UTI was also shown to be a strong inhibitor of nonplasmin mediated fibrinolysis.
摘要
尿胰蛋白酶抑制剂的三硝基苯基衍生物（TNP-UTI）显示出比完整的尿胰蛋白酶抑制剂强约50倍的抗纤溶酶纤维蛋白溶解作用。尿胰蛋白酶抑制剂修饰后，抗胰蛋白酶或抗糜蛋白酶活性几乎没有变化。TNP-UTI也被证明是一种非纤溶酶介导的纤维蛋白溶解的强效抑制剂。
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