巴西非鲍曼不动杆菌临床分离株中 IMP-1 的出现。
Occurrence of IMP-1 in non-baumannii Acinetobacter clinical isolates from Brazil.
机构信息
Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo, Brazil.
Universidade Federal de São Paulo - UNIFESP, Laboratório Especial de Microbiologia clínica - LEMC, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo, Brazil.
出版信息
J Med Microbiol. 2018 May;67(5):628-630. doi: 10.1099/jmm.0.000732. Epub 2018 Apr 6.
The aim of this study was to characterize the presence of carbapenemase-encoding genes in distinct species of Acinetobacter spp. isolated from Brazilian hospitals. Five carbapenem-resistant Acinetobacter spp. isolates (two Acinetobacter pittii, two Acinetobacter bereziniae and one Acinetobacter junii) recovered from two distinct hospitals between 2000 and 2016 were included in this study. All of the isolates harboured blaIMP-1, which was inserted into In86, a class 1 integron. Pulsed field gel eletrophoresis analysis showed that both A. pittii were identical, while the two A. berezinae isolates were considered to be clonally related. In this study, we demonstrated that mobile elements carrying carbapenemase-encoding genes such as In86 may persist for a long period, allowing their mobilization from A. baumannii to other Acinetobacter spp. that are usually susceptible to multiple antimicrobials.
本研究旨在对从巴西医院分离出的不同种属的耐碳青霉烯类鲍曼不动杆菌中碳青霉烯酶编码基因的存在情况进行分析。从 2000 年至 2016 年，从两家不同医院中选取了 5 株耐碳青霉烯类鲍曼不动杆菌（2 株鲍曼不动杆菌、2 株琼氏不动杆菌和 1 株约翰逊不动杆菌）作为研究对象。所有的分离株均携带 blaIMP-1 基因，该基因插入到了第一类整合子 In86 中。脉冲场凝胶电泳分析显示，2 株鲍曼不动杆菌是相同的，而 2 株琼氏不动杆菌分离株则被认为是克隆相关的。在本研究中，我们证明了可移动元件携带的碳青霉烯酶编码基因，如 In86，可能会持续存在很长时间，从而允许其从鲍曼不动杆菌转移到其他通常对多种抗生素敏感的不动杆菌属。
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