Genomic and Clinical Characterization of IMP-1-Producing Multidrug-Resistant Isolates from Bloodstream Infections in a Brazilian Tertiary Hospital.

is the main species of the genus; however, non- (NBA) species causing infections have been described for the past years, as well as antimicrobial resistance. In this study, we describe the occurrence of two multidrug-resistant (MDR) IMP-1-producing isolates recovered from bloodstream infections in different patients but in the same intensive care unit among 134 carbapenem-resistant screened. Antimicrobial susceptibility testing revealed resistance to carbapenems, extended spectrum, and antipseudomonad cephalosporins, amikacin, and trimethoprim-sulfamethoxazole. Both isolates shared the same I-pulsed-field gel electrophoresis (PFGE) pattern. Whole-genome sequencing of both isolates revealed that was embedded into an In86 Class I integron carrying also , , and genes. A new sequence type (ST1309 Pasteur) was deposited. The virulence genes and , seen in , were detected in the strains. Recognition of causing invasive MDR infection underscores the role of NBA species as human pathogens especially in at-risk patients.