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基于酶促酯交换脂肪的稳定化妆品制剂的评估,该制剂被提议用于预防特应性皮炎。

ASSESSMENT OF A STABLE COSMETIC PREPARATION BASED ON ENZYMATIC INTERESTERIFIED FAT, PROPOSED IN THE PREVENTION OF ATOPIC DERMATITIS.

作者信息

Kowalska Malgorzata, Mendrycka Mariola, Zbikowska Anna, Kowalska Dorota

出版信息

Acta Pol Pharm. 2017 Mar;74(2):465-476.

PMID:29624253
Abstract

Atopic dermatitis is one of the most common skin disorders seen in infants, children and adults. Proper prevention might slow the atopic symptoms. The purpose of the work was a sensory analysis, an evaluation of moistening properties and stability of emulsions based on an enzymatic interesterified fat blend (mutton tallow and walnut oil) and homogenized at different revolutions and different contents of thickener. The emulsions were evaluated with respect to sensory and skin moisturizing properties by 78 respondents. Stability tests, particle size, distribution, dispersity index, morphology structure of the emulsions were determinated too. Taking into consideration all properties of the emulsions, emulsion IV (containing 0.9 g carboxymethyl cellulose and homogenized at 18000 rpm) and emulsion V (1.5 g of carboxymethyl cellulose and homogenized at 24000 rpm) were found to be of optimum composition. The emulsions exhibited good stability, were highly rated in sensory terms and displayed optimum moistening properties. It has been proven that model emulsions based on interesterified fats containing partial acylglicerols, with optimum carboxymethyl cellulose content and specific revolutions at the time of homogenization are an opportunity for developing preparations targeted at skins requiring special care (e.g., with atopic dermatitis or psoriasis). The work proved the use of enzymatic process to create the emulsifier, which represents the innovative contribution of this work. Also it showed an additional application of enzymatic interesterified fats which since has been used only in food industries.

摘要

特应性皮炎是婴幼儿、儿童及成人中最常见的皮肤疾病之一。适当的预防措施或许可以减缓特应性症状。这项研究的目的是基于酶法酯交换脂肪混合物(羊脂和核桃油)并在不同转速及不同增稠剂含量下均质化后,对乳液进行感官分析、保湿性能评估及稳定性评估。78名受访者对这些乳液的感官和皮肤保湿性能进行了评估。同时还测定了乳液的稳定性测试、粒径、分布、分散指数及形态结构。综合考虑乳液的所有性能,发现乳液IV(含有0.9 g羧甲基纤维素并在18000转/分钟下均质化)和乳液V(1.5 g羧甲基纤维素并在24000转/分钟下均质化)具有最佳组成。这些乳液表现出良好的稳定性,在感官方面得到高度评价,并具有最佳的保湿性能。已证明,基于含有部分酰基甘油的酯交换脂肪、具有最佳羧甲基纤维素含量及均质化时特定转速的模型乳液,为开发针对需要特殊护理的皮肤(如患有特应性皮炎或牛皮癣的皮肤)的制剂提供了契机。这项研究证明了使用酶法工艺制备乳化剂,这是本研究的创新贡献。此外,它还展示了酶法酯交换脂肪的额外应用,此前该脂肪仅用于食品工业。

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