Gebarowski Tomasz, Gebczak Katarzyna, Wiatrak Benita, Kulma Anna, Pelc Katarzyna, Czuj Tadeusz, Szopa Jan, Gasiorowski Kazimierz
Acta Pol Pharm. 2017 Mar;74(2):653-659.
Emulsions made of oils from transgenic flaxseeds significantly decreased in vitro proliferation of six tested human cancer cell lines in 48-h cultures, as assessed with the standard sulforhodamine assay. However, the emulsions also increased proliferation rate of normal human dermal fibroblasts and, to a lower extend, of keratinocytes. Both inhibition of in vitro proliferation of human cancer cell lines and stimulation of proliferation of normal dermal fibroblasts and keratinocytes were especially strong with the emulsion type B and with emulsion type M. Oils from seeds of transgenic flax type B and M should be considered as valuable adjunct to standard cytostatic therapy of human cancers and also could be applied to improve the treatment of skin lesions in wound healing.
通过标准的磺基罗丹明检测法评估，由转基因亚麻籽提取的油制成的乳液在48小时培养中显著降低了六种受试人类癌细胞系的体外增殖。然而，这些乳液也提高了正常人皮肤成纤维细胞的增殖率，对角质形成细胞的增殖率也有一定程度的提高。B型乳液和M型乳液对人类癌细胞系体外增殖的抑制以及对正常皮肤成纤维细胞和角质形成细胞增殖的刺激作用尤为显著。B型和M型转基因亚麻籽的油应被视为人类癌症标准细胞抑制疗法的有价值辅助手段，也可用于改善伤口愈合中皮肤损伤的治疗。
