老年人骨重塑与代谢的关系

[Relationship between bone remodeling and metabolism in the elderly].

作者信息

Basurto-Acevedo Lourdes, Saucedo-García Renata, Vázquez-Martínez Ana, Cruz-García Miriam, Valle-Hernández María Magdalena, Rosales-Cruz Erika, Sánchez-Arenas Rosalinda

机构信息

Instituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Unidad de Investigación Médica en Enfermedades Endócrinas. Ciudad de México, México

出版信息

Rev Med Inst Mex Seguro Soc. 2018;56(Suppl 1):S6-S11.

PMID:29624339

Abstract

BACKGROUND

Recent studies have shown that osteocalcin (OC) is related to not only bone metabolism but also energy metabolism. The aim of the present study was to investigate whether OC was associated with metabolic factors and bone mineral density (BMD) in elderly men.

METHODS

A cross-sectional study was done including 122 healthy men aged 60 years or older. Serum glucose, lipids, insulin, adiponectin and OC were measured and BMD was estimated using dual energy X-ray absorptiometry.

RESULTS

42.8% of men had metabolic syndrome (MetS). OC levels were not significantly different between men with and without MetS. OC concentrations were inversely associated with body mass index (BMI) (r = −0.226, p = 0.04), waist circumference (r = −0.261, p = 0.02), glucose (r = −0.245, p = 0.03), insulin (r = −0.235, p = 0.03), and HOMA-IR (r = −0.211, p = 0.04). In addition, OC levels were higher in patients with diminished BMD compared with those with normal BMD.

CONCLUSIONS

OC levels correlate negatively with BMI, waist circumference, glucose, insulin and HOMA-IR in elderly men, which suggests a connection between bone and energy metabolism.

摘要

背景

最近的研究表明，骨钙素（OC）不仅与骨代谢有关，还与能量代谢有关。本研究的目的是调查老年男性中OC是否与代谢因素和骨密度（BMD）相关。

方法

进行了一项横断面研究，纳入了122名60岁及以上的健康男性。测量血清葡萄糖、脂质、胰岛素、脂联素和OC，并使用双能X线吸收法估计骨密度。

结果

42.8%的男性患有代谢综合征（MetS）。患有和未患有MetS的男性之间OC水平无显著差异。OC浓度与体重指数（BMI）呈负相关（r = -0.226，p = 0.04）、腰围（r = -0.261，p = 0.02）、葡萄糖（r = -0.245，p = 0.03）、胰岛素（r = -0.235，p = 0.03）和HOMA-IR（r = -0.211，p = 0.04）。此外，与骨密度正常的患者相比，骨密度降低的患者OC水平更高。