Onyenekwu Chinelo P, Azinge Elaine C, Egbuagha Ephraim U, Okpara Henry C
Department of Clinical Pathology, Lagos University Teaching Hospital, Idi-Araba, Lagos State, Nigeria.
Department of Clinical Pathology, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Idi-Araba, Lagos State, Nigeria.
Diabetes Metab Syndr. 2017 Oct-Dec;11(4):281-286. doi: 10.1016/j.dsx.2016.12.013. Epub 2016 Dec 15.
To determine the levels of plasma osteocalcin (OC) in Nigerians with type 2 diabetes mellitus (DM) and compare these to levels in non-diabetic controls (NDM). To assess the relationship of OC to glycaemic control and parameters of metabolic syndrome (MetS) and compare its levels in Nigerians with and without MetS.
The waist circumference (WC), body mass index (BMI) and blood pressure of 200 study participants were taken. Plasma osteocalcin, fasting glucose (FPG), glycated haemoglobin (HbA1c), high density lipoprotein cholesterol (HDL-c) and triglyceride (TG) levels were determined. Metabolic syndrome was defined by the International Diabetes Federation criteria. Statistical significance was set at 0.05.
Osteocalcin levels were lower in the DM group (p=0.002) and inversely related to FPG (r=-0.198, p=0.003), HbA1c (r=-0.313, p<0.001), BMI (r=-0.331, p<0.001), WC (r=-0.339, p<0.001) and TG (r=-0.145, p=0.040), but directly related to HDL-c levels (r=0.166, p=0.019). Osteocalcin was higher in participants without MetS (Median 8.75ng/mL IQR[5.48-12.68]ng/mL) than in those with MetS (Median 4.74ng/Ml, IQR[2.80-9.12]ng/mL), p<0.001.
Plasma osteocalcin levels are inversely associated with good glycaemic control and components of MetS and are lower in individuals with DM and in those with MetS. These findings support a vital role of the bone, in the regulation of glucose and energy metabolism, in Nigerians. Further extensive studies are required to explore the potentials of OC in the management of DM and MetS.
测定2型糖尿病（DM）尼日利亚患者的血浆骨钙素（OC）水平，并与非糖尿病对照组（NDM）的水平进行比较。评估OC与血糖控制及代谢综合征（MetS）参数的关系，并比较有和没有MetS的尼日利亚人的OC水平。
测量200名研究参与者的腰围（WC）、体重指数（BMI）和血压。测定血浆骨钙素、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、高密度脂蛋白胆固醇（HDL-c）和甘油三酯（TG）水平。代谢综合征根据国际糖尿病联盟标准定义。统计学显著性设定为0.05。
DM组的骨钙素水平较低（p = 0.002），且与FPG（r = -0.198，p = 0.003）、HbA1c（r = -0.313，p < 0.001）、BMI（r = -0.331，p < 0.001）、WC（r = -0.339，p < 0.001）和TG（r = -0.145，p = 0.040）呈负相关，但与HDL-c水平呈正相关（r = 0.166，p = 0.019）。没有MetS的参与者的骨钙素水平（中位数8.75ng/mL，四分位间距[5.48 - 12.68]ng/mL）高于有MetS的参与者（中位数4.74ng/Ml，四分位间距[2.80 - 9.12]ng/mL），p < 0.001。
血浆骨钙素水平与良好的血糖控制及MetS的组成成分呈负相关，在DM患者和有MetS的个体中较低。这些发现支持了骨骼在尼日利亚人葡萄糖和能量代谢调节中的重要作用。需要进一步进行广泛研究以探索OC在DM和MetS管理中的潜力。
