Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Prosthodontics, College of Dentistry, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Clin Implant Dent Relat Res. 2018 Aug;20(4):535-540. doi: 10.1111/cid.12607. Epub 2018 Apr 6.
It is postulated that peri-implant sulcular fluid (PISF) levels of advanced glycation end products (AGEs) are higher with high glycemic levels.
In the present clinico-biochemical study, we explored the clinical and radiographic peri-implant parameters and levels of AGEs among prediabetic, type 2 diabetic (T2DM), and non-diabetic patients and to evaluate the correlation of AGEs with clinical peri-implant parameters.
Ninety patients were divided into three groups of 30 patients each; group 1: patients with prediabetes; group 2: patients with T2DM; and group 3: non-diabetic individuals. Clinical and radiographic peri-implant parameters assessed included plaque index (PI), bleeding on probing (BOP), probing depth (PD), and marginal bone loss (MBL). PISF was collected and analyzed for AGEs levels using enzyme-linked immunosorbent assay. Between-group comparison of means was verified with Kruskal-Wallis test and Pearson correlation coefficient for correlations of AGE levels with peri-implant parameters.
Mean peri-implant PI, BOP, PD, and MBL was significantly higher in group 1 and 2 as compared with non-diabetic patients (P < .05). Mean PI, BOP, PD, and MBL were comparable between group 1 and group 2 patients (P > .05). Mean levels of AGEs in PISF were significantly higher among prediabetic and T2DM patients as compared with non-diabetic patients (P < .05). Between group 1 and group 2, mean levels of AGEs was significantly higher in group 2 (P < .05). A significant positive correlations were found between levels of AGEs and PD (P = .0371) and MBL (P = .0117) in T2DM patients, respectively.
Clinical and radiographic peri-implant parameters were worse and levels of AGEs in PISF were increased in individuals with prediabetes and T2DM. AGEs may play an important role in peri-implant inflammation in prediabetes and T2DM.
据推测，高血糖水平会导致种植体周围沟液（PISF）中晚期糖基化终产物（AGEs）的水平升高。
在本临床生物化学研究中，我们探讨了糖尿病前期、2 型糖尿病（T2DM）和非糖尿病患者的临床和影像学种植体周围参数以及 AGEs 水平，并评估了 AGEs 与临床种植体周围参数的相关性。
将 90 名患者分为 3 组，每组 30 名患者；组 1：糖尿病前期患者；组 2：T2DM 患者；组 3：非糖尿病个体。评估的临床和影像学种植体周围参数包括菌斑指数（PI）、探诊出血（BOP）、探诊深度（PD）和边缘骨丧失（MBL）。收集 PISF 并使用酶联免疫吸附试验分析 AGEs 水平。使用 Kruskal-Wallis 检验和 Pearson 相关系数验证组间均值比较，用于评估 AGE 水平与种植体周围参数的相关性。
与非糖尿病患者相比，组 1 和 2 的种植体周围平均 PI、BOP、PD 和 MBL 显著升高（P<0.05）。组 1 和 2 患者的平均 PI、BOP、PD 和 MBL 无差异（P>0.05）。与非糖尿病患者相比，糖尿病前期和 T2DM 患者的 PISF 中 AGEs 水平显著升高（P<0.05）。组 2 的 AGEs 水平明显高于组 1（P<0.05）。在 T2DM 患者中，分别发现 AGEs 水平与 PD（P=0.0371）和 MBL（P=0.0117）呈显著正相关。
糖尿病前期和 T2DM 患者的临床和影像学种植体周围参数较差，PISF 中的 AGEs 水平升高。AGEs 可能在糖尿病前期和 T2DM 的种植体周围炎症中发挥重要作用。
