人多能干细胞衍生内胚层用于发育建模和临床应用。
Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications.
机构信息
Wellcome Trust - MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0SZ, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
Wellcome Trust - MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge CB2 0SZ, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
出版信息
Cell Stem Cell. 2018 Apr 5;22(4):485-499. doi: 10.1016/j.stem.2018.03.016.
The liver, lung, pancreas, and digestive tract all originate from the endoderm germ layer, and these vital organs are subject to many life-threatening diseases affecting millions of patients. However, primary cells from endodermal organs are often difficult to grow in vitro. Human pluripotent stem cells thus hold great promise for generating endoderm cells and their derivatives as tools for the development of new therapeutics against a variety of global healthcare challenges. Here we describe recent advances in methods for generating endodermal cell types from human pluripotent stem cells and their use for disease modeling and cell-based therapy.
肝脏、肺脏、胰腺和消化道均起源于内胚层，这些重要器官易患多种危及生命的疾病，影响着数以百万计的患者。然而，内胚层器官的原代细胞通常难以在体外生长。人类多能干细胞为生成内胚层细胞及其衍生物提供了巨大的希望，可作为开发针对各种全球医疗保健挑战的新型治疗方法的工具。本文将介绍人类多能干细胞生成内胚层细胞类型的最新方法及其在疾病建模和基于细胞的治疗中的应用。
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