Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement. 2018 Aug;14(8):989-997. doi: 10.1016/j.jalz.2018.02.013. Epub 2018 Apr 5.
We examined and compared plasma phospho-tau181 (pTau181) and total tau: (1) across the Alzheimer's disease (AD) clinical spectrum; (2) in relation to brain amyloid β (Aβ) positron emission tomography (PET), tau PET, and cortical thickness; and (3) as a screening tool for elevated brain Aβ.
Participants included 172 cognitively unimpaired, 57 mild cognitively impaired, and 40 AD dementia patients with concurrent Aβ PET (Pittsburgh compound B), tau PET (AV1451), magnetic resonance imaging, plasma total tau, and pTau181.
Plasma total tau and pTau181 levels were higher in AD dementia patients than those in cognitively unimpaired. Plasma pTau181 was more strongly associated with both Aβ and tau PET. Plasma pTau181 was a more sensitive and specific predictor of elevated brain Aβ than total tau and was as good as, or better than, the combination of age and apolipoprotein E (APOE).
Plasma pTau181 may have utility as a biomarker of AD pathophysiology and as a noninvasive screener for elevated brain Aβ.
我们考察并比较了阿尔茨海默病（AD）临床谱中血浆磷酸化tau181（pTau181）和总tau：（1）；（2）与脑β淀粉样蛋白（Aβ）正电子发射断层扫描（PET）、tau PET 和皮质厚度的关系；（3）作为检测脑 Aβ升高的筛查工具。
参与者包括 172 名认知正常、57 名轻度认知障碍和 40 名 AD 痴呆患者，他们同时进行了 Aβ PET（匹兹堡化合物 B）、tau PET（AV1451）、磁共振成像、血浆总 tau 和 pTau181 检测。
AD 痴呆患者的血浆总 tau 和 pTau181 水平高于认知正常者。血浆 pTau181 与 Aβ 和 tau PET 的相关性更强。与总 tau 相比，血浆 pTau181 对脑 Aβ升高的预测更敏感、更特异，与年龄和载脂蛋白 E（APOE）联合相比，其预测效果相当或更好。
血浆 pTau181 可能作为 AD 病理生理学的生物标志物和脑 Aβ 升高的非侵入性筛查工具具有一定的应用价值。
