Centre for Drug Research, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
J Ethnopharmacol. 2018 Jul 15;221:30-36. doi: 10.1016/j.jep.2018.04.005. Epub 2018 Apr 5.
Mitragyna speciosa (Korth.) also known as kratom, is a native medicinal plant of Southeast Asia with opioid-like effects. Kratom tea/juice have been traditionally used as a folk remedy and for controlling opiate withdrawal in Malaysia. Long-term opioid use is associated with depletion in testosterone levels.
Since kratom is reported to deform sperm morphology and reduce sperm motility, we aimed to clinically investigate the testosterone levels following long-term kratom tea/juice use in regular kratom users.
A total of 19 regular kratom users were recruited for this cross-sectional study. A full-blood test was conducted including determination of testosterone level, follicle stimulating hormone (FSH) and luteinizing hormone (LH) profile, as well as hematological and biochemical parameters of participants.
We found long-term kratom tea/juice consumption with a daily mitragynine dose of 76.23-94.15 mg did not impair testosterone levels, or gonadotrophins, hematological and biochemical parameters in regular kratom users.
Regular kratom tea/juice consumption over prolonged periods (>2 years) was not associated with testosterone impairing effects in humans.
Mitragyna speciosa（Korth.），俗称 kratom，是一种原产于东南亚的药用植物，具有类阿片样作用。在马来西亚，kratom 茶/汁一直被用作民间疗法和控制阿片类药物戒断。长期使用阿片类药物与睾丸激素水平下降有关。
由于 kratom 被报道会使精子形态变形并降低精子活力，我们旨在临床研究长期饮用 kratom 茶/汁对经常饮用 kratom 的人的睾丸激素水平的影响。
共招募了 19 名经常饮用 kratom 的人进行这项横断面研究。对参与者进行了全血检查，包括测定睾丸激素水平、卵泡刺激素（FSH）和黄体生成素（LH）谱以及血液学和生化参数。
我们发现，长期饮用 kratom 茶/汁，每天摄入的 mitragynine 剂量为 76.23-94.15mg，不会影响经常饮用 kratom 的人的睾丸激素水平或促性腺激素、血液学和生化参数。
长期（>2 年）饮用 kratom 茶/汁与人类睾丸激素损伤无关。
