咖啡饮用与主动脉瓣狭窄风险：一项前瞻性研究。

Coffee consumption and risk of aortic valve stenosis: A prospective study.

机构信息

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

出版信息

Nutr Metab Cardiovasc Dis. 2018 Aug;28(8):803-807. doi: 10.1016/j.numecd.2018.01.016. Epub 2018 Feb 7.

DOI:10.1016/j.numecd.2018.01.016

PMID:29627121

Abstract

BACKGROUND AND AIMS

Coffee contains many biologically active compounds with potential adverse or beneficial effects on the cardiovascular system. Whether coffee consumption is associated with the risk of aortic valve stenosis (AVS) is unknown. The purpose of this study was therefore to examine the association between coffee consumption and AVS incidence.

METHODS AND RESULTS

This prospective study included 71 178 men and women who provided information on their coffee consumption through a questionnaire at baseline. Incident cases of AVS were identified through linkage with the Swedish National Patient and Cause of Death Registers. During a mean follow-up of 15.2 years, 1295 participants (777 men and 518 women) were diagnosed with AVS. Coffee consumption was positively associated with risk of AVS in a dose-response manner after adjustment for age, sex, smoking, and other risk factors (P-trend = 0.005). The multivariable hazard ratios were was 1.11 (95% confidence interval 1.04-1.19) per 2 cups/day increase of coffee consumption and 1.65 (95% confidence interval 1.10-2.48) when comparing the highest (≥6 cups/day) with the lowest (<0.5 cup/day) category of coffee consumption. The association was not modified by other risk factors.

CONCLUSIONS

This study provides novel evidence that high coffee consumption is associated with an increased risk of AVS.

摘要

背景与目的

咖啡含有许多具有潜在不良或有益心血管系统作用的生物活性化合物。喝咖啡是否与主动脉瓣狭窄（AVS）的风险相关尚不清楚。因此，本研究旨在研究咖啡摄入量与 AVS 发病风险之间的关系。

方法和结果

本前瞻性研究纳入了 71178 名男性和女性，他们在基线时通过问卷提供了关于咖啡摄入量的信息。通过与瑞典国家患者和死因登记册的链接，确定了 AVS 的发病病例。在平均 15.2 年的随访期间，有 1295 名参与者（777 名男性和 518 名女性）被诊断为 AVS。在调整年龄、性别、吸烟和其他危险因素后，咖啡摄入量与 AVS 风险呈剂量反应关系（P 趋势=0.005）。多变量风险比为，咖啡摄入量每增加 2 杯/天，风险增加 1.11（95%置信区间 1.04-1.19），而最高（≥6 杯/天）与最低（<0.5 杯/天）咖啡摄入量组相比，风险增加 1.65（95%置信区间 1.10-2.48）。该关联不受其他危险因素的影响。