Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Departments of Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
J Natl Cancer Inst. 2017 Mar 1;109(3):1-3. doi: 10.1093/jnci/djw237.
Evidence indicates that coffee consumption may reduce the risk of gallstone disease, which is strongly associated with increased risk of gallbladder cancer. The association between coffee consumption and gallbladder cancer incidence was examined in a prospective cohort study of 72 680 Swedish adults (aged 45 - 83 years) who were free of cancer and reported their coffee consumption at baseline. Gallbladder cancers were ascertained by linkage with the Swedish Cancer Register. The data were analyzed using Cox proportional hazards regression models. Statistical tests were two-sided. During 967 377 person-years of follow-up, 74 gallbladder cancer case patients were identified. Compared with consumption of one or less cups of coffee per day, the multivariable hazard ratios were 0.76 (95% confidence interval [CI] = 0.41 to 1.41) for two cups per day, 0.50 (95% CI = 0.24 to 1.06) for three cups per day, and 0.41 (95% CI = 0.20 to 0.83) for four or more cups per day. In conclusion, coffee consumption is associated with a reduced risk of gallbladder cancer.
有证据表明，喝咖啡可能降低胆结石病的风险，而胆结石病与胆囊癌风险增加密切相关。在一项对 72680 名瑞典成年人（年龄 45 岁至 83 岁）的前瞻性队列研究中，研究人员考察了喝咖啡与胆囊癌发病率之间的关系。这些成年人在研究开始时报告了他们的咖啡摄入量，且没有癌症。通过与瑞典癌症登记处的链接确定胆囊癌病例。使用 Cox 比例风险回归模型分析数据。统计检验为双侧检验。在 967377 人年的随访期间，确定了 74 例胆囊癌病例患者。与每天饮用一杯或更少杯咖啡相比，每天饮用两杯、三杯和四杯或更多杯咖啡的多变量风险比分别为 0.76（95%置信区间[CI] = 0.41 至 1.41）、0.50（95% CI = 0.24 至 1.06）和 0.41（95% CI = 0.20 至 0.83）。总之，喝咖啡与胆囊癌风险降低相关。
