Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Photodiagnosis Photodyn Ther. 2018 Jun;22:166-168. doi: 10.1016/j.pdpdt.2018.04.002. Epub 2018 Apr 5.
Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm arising in apocrine rich area of the skin. It is divided into primary and secondary EMPD based on whether there is an underlying malignancy, either local apocrine cancers or distant neoplasms. Therefore, all patients with EMPD should undergo an extensive and targeted cancer workup, depending on the histological staining pattern and the location. Surgical removal is considered the mainstay of treatment for patients with EMPD. Herein, we present a case of secondary EMPD where photodynamic therapy was effective in terms of improving symptoms and quality of life. Owing to preexisting comorbid conditions, large area of disease and risk of post-surgery mutilation and functional impairment, surgery could not be elected for this patient, necessitating nonsurgical approach.
乳房外帕哲氏病（EMPD）是一种罕见的皮肤顶泌汗腺丰富区域上皮内肿瘤。根据是否存在潜在恶性肿瘤，即局部顶泌汗腺癌或远处肿瘤，将其分为原发性和继发性 EMPD。因此，所有 EMPD 患者均应根据组织学染色模式和位置进行广泛和针对性的癌症检查。手术切除被认为是 EMPD 患者的主要治疗方法。在此，我们报告了一例继发性 EMPD，光动力疗法在改善症状和生活质量方面是有效的。由于存在先前的合并症、大面积疾病以及术后致残和功能障碍的风险，该患者不能选择手术，需要采用非手术方法。
