Department of Medicine, Division of Nephrology, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
Sidney Kimmel College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Cardiorenal Med. 2018;8(2):160-172. doi: 10.1159/000487646. Epub 2018 Apr 4.
Preeclampsia is a multisystem vascular disorder of pregnancy that remains a leading cause of maternal and fetal morbidity and mortality. Preeclampsia remains an underrecognized risk factor for future cardiovascular and kidney disease in women and represents the confluence of preexisting vascular risk factors with superimposed endothelial injury from placental mediated anti-angiogenic factors.
This review highlights the close relationship between preeclampsia and future cardiovascular and kidney disease. It describes the pathophysiology and current understanding of biomarkers that form the molecular signature for long-term endothelial dysfunction in preeclamptic women. Finally, it describes strategies for early identification and management of women with preeclampsia with elevated risk for cardiovascular and kidney disease. Key Messages: Future rigorous studies on cardiovascular risk modification in this phenotype of disease are essential to reduce the burden of cardiovascular and kidney disease, in women with preeclampsia.
子痫前期是一种妊娠多系统血管疾病，仍然是孕产妇发病率和死亡率的主要原因。子痫前期仍然是女性未来心血管和肾脏疾病的未被充分认识的危险因素，代表了先前存在的血管危险因素与胎盘介导的抗血管生成因子引起的内皮损伤的融合。
本文重点介绍了子痫前期与未来心血管和肾脏疾病之间的密切关系。它描述了子痫前期女性长期内皮功能障碍的病理生理学和目前对生物标志物的理解，这些生物标志物形成了分子特征。最后，它描述了早期识别和管理子痫前期妇女心血管和肾脏疾病风险升高的策略。
未来针对该疾病表型的心血管风险修正的严格研究对于降低患有子痫前期的女性的心血管和肾脏疾病负担至关重要。
