Marshall S M, Home P D, Taylor R, Alberti K G
Department of Medicine, New Medical School, Newcastle upon Tyne, UK.
Diabet Med. 1987 Nov-Dec;4(6):521-5. doi: 10.1111/j.1464-5491.1987.tb00922.x.
Twelve C-peptide negative insulin-dependent diabetic patients participated in a randomized cross-over study of 6 months treatment with twice or thrice daily insulin injection therapy and continuous subcutaneous insulin infusion (CSII). Standard, non-intensified management conditions were maintained throughout. Glycosylated haemoglobin levels were similar on both regimens (9.2 +/- 0.5% versus 9.0 +/- 0.4%; CSII vs injection therapy; (mean +/- SEM). Capillary blood glucose concentrations before breakfast (5.2 +/- 0.4 mmol/l vs 9.1 +/- 0.8 mmol/l), after lunch (6.5 mmol/l +/- 0.8 vs 7.9 +/- 1.0 mmol/l) and before the evening meal (5.0 +/- 0.7 mmol/l vs 7.7 +/- 0.7 mmol/l) were lower on CSII, as were 24-hour urine glucose excretion and total insulin dose (39.3 +/- 2.2 vs 49.8 +/- 4.0 U/day). There was a significant positive correlation between fasting blood glucose values and glycosylated haemoglobin on injection but not pump treatment. Thus although blood glucose control at some individual daytime points appeared lower on CSII, overall diabetic control was similar on the two regimens.
12名C肽阴性胰岛素依赖型糖尿病患者参与了一项为期6个月的随机交叉研究，该研究对比了每日两次或三次胰岛素注射疗法与持续皮下胰岛素输注（CSII）对患者的治疗效果。研究全程保持标准的、非强化管理条件。两种治疗方案下糖化血红蛋白水平相似（分别为9.2±0.5%和9.0±0.4%；CSII组与注射治疗组；均值±标准误）。CSII组早餐前毛细血管血糖浓度（5.2±0.4 mmol/l对比9.1±0.8 mmol/l）、午餐后（6.5±0.8 mmol/l对比7.9±1.0 mmol/l）以及晚餐前（5.0±0.7 mmol/l对比7.7±0.7 mmol/l）均较低，24小时尿糖排泄量和胰岛素总剂量也较低（分别为39.3±2.2对比49.8±4.0 U/天）。注射治疗时空腹血糖值与糖化血红蛋白之间存在显著正相关，而泵治疗时则不存在。因此，尽管CSII在某些个体日间时间点的血糖控制似乎较低，但两种治疗方案的总体糖尿病控制效果相似。
