Eshøj O, Feldt-Rasmussen B, Larsen M L, Mogensen E F
Medical Department M, Odense University Hospital, Denmark.
Diabet Med. 1987 Nov-Dec;4(6):531-3. doi: 10.1111/j.1464-5491.1987.tb00924.x.
With the aim of comparing different urine collection periods in the assessment of micro-albuminuria, urinary albumin excretion rates (AERs) were measured in samples from 24 h, overnight, and morning urine collections in 54 patients aged 17 to 62 years with insulin-dependent diabetes mellitus with a mean duration of 15 years. The AER in overnight urine was found to be reduced by 25% compared to the rate in 24 h and morning urine. Assessing the ability to predict a 24 h AER within the microalbuminuric range (20-200 micrograms/min) we found a sensitivity of 90% and a specificity of 88% for both overnight and morning urine samples. These values were slightly improved by relating AER to the excretion of creatinine and it is concluded that overnight as well as morning urine collections can be used when diagnosing microalbuminuria in insulin-dependent diabetics. Furthermore the results show that the albumin to creatinine ratio in morning urine is a reliable estimate of 24 h AER and better than measurement of the albumin concentration alone.
为了比较不同尿液收集时间段在微量白蛋白尿评估中的作用，对54例年龄在17至62岁、平均病程15年的胰岛素依赖型糖尿病患者分别采集24小时、夜间及晨尿样本，测量尿白蛋白排泄率（AER）。结果发现，夜间尿AER比24小时尿及晨尿的降低了25%。在评估微量白蛋白尿范围内（20 - 200微克/分钟）预测24小时AER的能力时，我们发现夜间及晨尿样本的敏感性均为90%，特异性均为88%。将AER与肌酐排泄量相关联后，这些数值略有改善。由此得出结论，在诊断胰岛素依赖型糖尿病患者的微量白蛋白尿时，夜间及晨尿收集均可采用。此外，结果表明晨尿中的白蛋白与肌酐比值是24小时AER的可靠估计值，优于单独测量白蛋白浓度。
