Nano-Bio Science Research Group, DTU Food, Technical University of Denmark, Kemitorvet 202, 2800 Kgs, Lyngby, Denmark.
Nano-Bio Science Research Group, DTU Food, Technical University of Denmark, Kemitorvet 202, 2800 Kgs, Lyngby, Denmark.
Carbohydr Polym. 2018 Jun 15;190:240-247. doi: 10.1016/j.carbpol.2018.02.062. Epub 2018 Feb 24.
The efficacy of chitosan (CS) to be used as drug delivery carrier has previously been reported. However, limited work has been pursued to produce stable and mucoadhesive CS electrosprayed particles for oral drug delivery, which is the aim of this study. Various CS types with different molecular weight (MW), degree of deacetylation (DD), and degree of polymerization (DP) were assessed. In addition, the effect of the solvent composition was also investigated. Results showed that stable CS electrosprayed particles can be produced by dissolving 3% w/v of low MW CS in mixtures of aqueous acetic acid and ethanol (50/50% v/v). The stable CS particles displayed diameters of approximately 1 μm as determined by dynamic light scattering. The zeta potential of these particles was found to be approximately 40 mV confirming the mucoadhesion properties of these CS electrosprayed particles and its potential to be used as drug delivery carrier.
壳聚糖（CS）作为药物递送载体的功效先前已有报道。然而，目前用于生产稳定且具有黏膜黏附性的 CS 电喷雾粒子以用于口服药物递送的研究还很有限，本研究旨在解决这一问题。本研究评估了不同类型的 CS，其分子量（MW）、脱乙酰度（DD）和聚合度（DP）各不相同。此外，还研究了溶剂组成的影响。结果表明，将低 MW CS 溶解在含有 3% w/v 的水合乙酸和乙醇（50/50% v/v）的混合物中，可以制备出稳定的 CS 电喷雾粒子。通过动态光散射法确定，这些稳定的 CS 粒子的直径约为 1 µm。这些粒子的 Zeta 电位约为 40 mV，证实了这些 CS 电喷雾粒子的黏膜黏附特性及其作为药物递送载体的潜力。
