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Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer.

作者信息

Tan Shuangyan, Gou Qiheng, Pu Wenchen, Guo Chenglin, Yang Yun, Wu Ke, Liu Yaxin, Liu Lunxu, Wei Yu-Quan, Peng Yong

机构信息

Department of Thoracic Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, 610041, Chengdu, China.

CAS Key Lab for Computational Biology, CAS Center for Excellence in Molecular Cell Science, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China.

出版信息

Cell Res. 2018 Jun;28(6):693-695. doi: 10.1038/s41422-018-0033-7. Epub 2018 Apr 8.

DOI:10.1038/s41422-018-0033-7
PMID:29628502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5993747/
Abstract
摘要

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Circular RNA F-circEA produced from EML4-ALK fusion gene as a novel liquid biopsy biomarker for non-small cell lung cancer.由EML4-ALK融合基因产生的环状RNA F-circEA作为非小细胞肺癌的一种新型液体活检生物标志物。
Cell Res. 2018 Jun;28(6):693-695. doi: 10.1038/s41422-018-0033-7. Epub 2018 Apr 8.
2
Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer.环状 RNA F-circEA-2a 来源于 EML4-ALK 融合基因，可促进非小细胞肺癌细胞的迁移和侵袭。
Mol Cancer. 2018 Sep 20;17(1):138. doi: 10.1186/s12943-018-0887-9.
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Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.外显子数组分析在乳腺癌、结直肠癌和非小细胞肺癌中检测到 EML4-ALK 融合。
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4
EML4-ALK induces epithelial-mesenchymal transition consistent with cancer stem cell properties in H1299 non-small cell lung cancer cells.EML4-ALK在H1299非小细胞肺癌细胞中诱导上皮-间质转化，这与癌症干细胞特性一致。
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5
EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers.EML4-ALK融合与一部分肺癌的组织学特征相关。
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Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene.具有 EML4-ALK 融合基因的非小细胞肺癌的临床病理特征。
Ann Surg Oncol. 2010 Mar;17(3):889-97. doi: 10.1245/s10434-009-0808-7.
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A novel mechanism of EML4-ALK rearrangement mediated by chromothripsis in a patient-derived cell line.在一个患者来源的细胞系中，通过染色体重排导致 EML4-ALK 重排的一种新机制。
J Thorac Oncol. 2014 Nov;9(11):1638-46. doi: 10.1097/JTO.0000000000000311.
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Detection of EML4-ALK fusion genes in non-small cell lung cancer patients with clinical features associated with EGFR mutations.检测具有 EGFR 突变相关临床特征的非小细胞肺癌患者中的 EML4-ALK 融合基因。
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Clinicopathologic features of patients with non-small cell lung cancer harboring the EML4-ALK fusion gene: a meta-analysis.携带EML4-ALK融合基因的非小细胞肺癌患者的临床病理特征：一项荟萃分析。
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Protocol Design for the Bench to Bed Trial in Alectinib-Refractory Non-Small-Cell Lung Cancer Patients Harboring the EML4-ALK Fusion Gene (ALRIGHT/OLCSG1405).针对携带EML4-ALK融合基因的阿来替尼难治性非小细胞肺癌患者的从实验室到临床研究的方案设计（ALRIGHT/OLCSG1405）
Clin Lung Cancer. 2016 Nov;17(6):602-605. doi: 10.1016/j.cllc.2016.05.005. Epub 2016 Jun 2.

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Defining the landscape of circRNAs in non-small cell lung cancer and their potential as liquid biopsy biomarkers: a complete review including current methods.界定非小细胞肺癌中环状RNA的格局及其作为液体活检生物标志物的潜力：包括当前方法的全面综述
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本文引用的文献

1
Non-small-cell lung cancer.非小细胞肺癌。
Nat Rev Dis Primers. 2015 May 21;1:15009. doi: 10.1038/nrdp.2015.9.
2
Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.致癌融合环状 RNA 来源于与癌症相关的染色体易位。
Cell. 2016 Apr 7;165(2):289-302. doi: 10.1016/j.cell.2016.03.020. Epub 2016 Mar 31.
3
The biogenesis and emerging roles of circular RNAs.环状 RNA 的生物发生和新兴作用。
Nat Rev Mol Cell Biol. 2016 Apr;17(4):205-11. doi: 10.1038/nrm.2015.32. Epub 2016 Feb 24.
4
Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis.环状RNA在外泌体中富集且稳定：一种有前景的癌症诊断生物标志物。
Cell Res. 2015 Aug;25(8):981-4. doi: 10.1038/cr.2015.82. Epub 2015 Jul 3.
5
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.哺乳动物脑中的环状 RNA 丰度高、保守且表达具有动态性。
Mol Cell. 2015 Jun 4;58(5):870-85. doi: 10.1016/j.molcel.2015.03.027. Epub 2015 Apr 23.
6
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.EML4-ALK融合基因与ALK激酶抑制剂在肺癌中的疗效
Clin Cancer Res. 2008 Jul 1;14(13):4275-83. doi: 10.1158/1078-0432.CCR-08-0168.
7
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.非小细胞肺癌中转化型EML4-ALK融合基因的鉴定。
Nature. 2007 Aug 2;448(7153):561-6. doi: 10.1038/nature05945. Epub 2007 Jul 11.