Sukenaga Norihiko, Hirose Munetaka
Department of Anesthesiology and Pain Medicine, Hyogo College of Medicine, Hyogo, Japan.
Anesth Essays Res. 2018 Jan-Mar;12(1):279-281. doi: 10.4103/aer.AER_179_17.
Transient receptor potential (TRP) channels play key roles for the transition from acute to chronic postoperative pain after surgery. To evaluate TRP channels in the peripheral blood cells as blood biomarkers for chronic pain, we collected blood samples for genome-wide assays of the mRNA expression and assessed pain intensity and the number of pain symptoms in 13 patients with chronic pain. There was a significant association between increases in the number of pain symptoms and increases in the TRP vanilloid 1 (TRPV1) expression. Decreases in the TRP ankyrin 1 (TRPA1) expression, however, tended to increase the number of pain symptoms. There was likely an inverse relationship for TRPV1 and TRPA1 expressions with regard to the number of pain symptoms in chronic pain patients.
瞬时受体电位（TRP）通道在手术后急性疼痛向慢性疼痛的转变中起关键作用。为了评估外周血细胞中的TRP通道作为慢性疼痛的血液生物标志物，我们采集了血液样本进行全基因组mRNA表达分析，并评估了13名慢性疼痛患者的疼痛强度和疼痛症状数量。疼痛症状数量的增加与TRP香草酸受体1（TRPV1）表达的增加之间存在显著关联。然而，TRP锚蛋白1（TRPA1）表达的降低往往会增加疼痛症状的数量。在慢性疼痛患者中，TRPV1和TRPA1的表达与疼痛症状数量之间可能存在负相关关系。
