瞬时受体电位通道作为慢性疼痛患者疼痛特征的血液生物标志物
Transient Receptor Potential Channels as Blood Biomarkers for Pain Characteristics in Patients with Chronic Pain.
作者信息
Sukenaga Norihiko, Hirose Munetaka
机构信息
Department of Anesthesiology and Pain Medicine, Hyogo College of Medicine, Hyogo, Japan.
出版信息
Anesth Essays Res. 2018 Jan-Mar;12(1):279-281. doi: 10.4103/aer.AER_179_17.
Abstract
Transient receptor potential (TRP) channels play key roles for the transition from acute to chronic postoperative pain after surgery. To evaluate TRP channels in the peripheral blood cells as blood biomarkers for chronic pain, we collected blood samples for genome-wide assays of the mRNA expression and assessed pain intensity and the number of pain symptoms in 13 patients with chronic pain. There was a significant association between increases in the number of pain symptoms and increases in the TRP vanilloid 1 (TRPV1) expression. Decreases in the TRP ankyrin 1 (TRPA1) expression, however, tended to increase the number of pain symptoms. There was likely an inverse relationship for TRPV1 and TRPA1 expressions with regard to the number of pain symptoms in chronic pain patients.
摘要
瞬时受体电位（TRP）通道在手术后急性疼痛向慢性疼痛的转变中起关键作用。为了评估外周血细胞中的TRP通道作为慢性疼痛的血液生物标志物，我们采集了血液样本进行全基因组mRNA表达分析，并评估了13名慢性疼痛患者的疼痛强度和疼痛症状数量。疼痛症状数量的增加与TRP香草酸受体1（TRPV1）表达的增加之间存在显著关联。然而，TRP锚蛋白1（TRPA1）表达的降低往往会增加疼痛症状的数量。在慢性疼痛患者中，TRPV1和TRPA1的表达与疼痛症状数量之间可能存在负相关关系。
相似文献
1
Transient Receptor Potential Channels as Blood Biomarkers for Pain Characteristics in Patients with Chronic Pain.瞬时受体电位通道作为慢性疼痛患者疼痛特征的血液生物标志物
Anesth Essays Res. 2018 Jan-Mar;12(1):279-281. doi: 10.4103/aer.AER_179_17.
2
Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome.肠易激综合征患者黏膜下神经元中组氨酸介导的瞬时受体电位（TRP）锚蛋白 1 和 TRP 香草素 4 信号转导的增强作用。
Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G338-G349. doi: 10.1152/ajpgi.00116.2018. Epub 2019 Jan 10.
3
Feeling hot, feeling cold: TRP channels-a great story unfolds.感受热，感受冷：瞬时受体电位通道——一个精彩的故事正在展开。
Temperature (Austin). 2015 May 26;2(2):150-1. doi: 10.1080/23328940.2015.1047721. eCollection 2015 Apr-Jun.
4
Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1.瞬时受体电位锚蛋白 1 对瞬时受体香草素 1 活性的调制。
Mol Pharmacol. 2014 Feb;85(2):335-44. doi: 10.1124/mol.113.088997. Epub 2013 Nov 25.
5
Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain.内源性瞬时受体电位锚蛋白 1 和香草素 1 活性增强炎症痛时脊髓 I 层神经元的谷氨酸能传入。
J Neurochem. 2019 May;149(3):381-398. doi: 10.1111/jnc.14677. Epub 2019 Mar 26.
6
A novel 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime compound is a potent Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and V1) receptor antagonist.一种新型的3-(4,5-二苯基-1,3-恶唑-2-基)丙醛肟化合物是一种有效的瞬时受体电位锚蛋白1和香草酸受体1（TRPA1和V1）受体拮抗剂。
Neuroscience. 2016 Jun 2;324:151-62. doi: 10.1016/j.neuroscience.2016.02.049. Epub 2016 Feb 27.
7
Involvement of TRPV1 and TRPA1 in incisional intraoral and extraoral pain.瞬时受体电位香草酸亚型1（TRPV1）和瞬时受体电位锚蛋白1（TRPA1）与口腔内外切口疼痛的关系。
J Dent Res. 2015 Mar;94(3):446-54. doi: 10.1177/0022034514565645. Epub 2015 Jan 9.
8
Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels.配体发挥偏向性活性以调节西格玛1受体与阳离子瞬时受体电位锚蛋白1、瞬时受体电位香草酸亚型1和瞬时受体电位M型8通道的相互作用。
Front Pharmacol. 2019 Jun 12;10:634. doi: 10.3389/fphar.2019.00634. eCollection 2019.
9
Lysophosphatidic acid-induced itch is mediated by signalling of LPA receptor, phospholipase D and TRPA1/TRPV1.溶血磷脂酸诱导的瘙痒是由溶血磷脂酸受体、磷脂酶D和瞬时受体电位锚蛋白1/瞬时受体电位香草酸亚型1的信号传导介导的。
J Physiol. 2017 Apr 15;595(8):2681-2698. doi: 10.1113/JP273961. Epub 2017 Mar 22.
10
Roles of Transient Receptor Potential Ankyrin 1 in Oxaliplatin-Induced Peripheral Neuropathy.瞬时受体电位锚蛋白1在奥沙利铂诱导的周围神经病变中的作用
Biol Pharm Bull. 2017;40(7):947-953. doi: 10.1248/bpb.b17-00243.
引用本文的文献
1
Childhood traumatization is associated with differences in TRPA1 promoter methylation in female patients with multisomatoform disorder with pain as the leading bodily symptom.童年期创伤与以躯体疼痛为主要症状的多发性躯体形式障碍女性患者 TRPA1 启动子甲基化差异相关。
Clin Epigenetics. 2019 Aug 28;11(1):126. doi: 10.1186/s13148-019-0731-0.
本文引用的文献
1
The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1.TRPA1离子通道在CD4+ T细胞中表达，并通过抑制TRPV1来抑制T细胞介导的结肠炎。
Gut. 2017 Sep;66(9):1584-1596. doi: 10.1136/gutjnl-2015-310710. Epub 2016 Jun 20.
2
Correlation Between DNA Methylation of TRPA1 and Chronic Pain States in Human Whole Blood Cells.人全血细胞中TRPA1基因DNA甲基化与慢性疼痛状态的相关性
Pain Med. 2016 Oct;17(10):1906-1910. doi: 10.1093/pm/pnv088. Epub 2016 Feb 5.
3
Transient Receptor Potential (TRP) channels in T cells.T细胞中的瞬时受体电位（TRP）通道。
Semin Immunopathol. 2016 May;38(3):309-19. doi: 10.1007/s00281-015-0535-z. Epub 2015 Oct 14.
4
Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons.模式识别受体以及瞬时受体电位家族的离子通道对危险和病原体相关分子模式的识别，会触发免疫细胞和感觉神经元中的炎性小体激活。
J Neuroinflammation. 2015 Feb 3;12:21. doi: 10.1186/s12974-015-0239-2.
5
Differential methylation of the TRPA1 promoter in pain sensitivity.疼痛敏感性中TRPA1启动子的差异甲基化
Nat Commun. 2014;5:2978. doi: 10.1038/ncomms3978.
6
Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls.药物难治性抑郁症女性与健康非抑郁对照者白细胞基因表达的失调
BMC Psychiatry. 2013 Oct 21;13:273. doi: 10.1186/1471-244X-13-273.
7
Transient receptor potential ion channels: powerful regulators of cell function.瞬时受体电位离子通道：细胞功能的强大调节者。
Ann Surg. 2014 Feb;259(2):229-35. doi: 10.1097/SLA.0b013e3182a6359c.
8
The role of the immune system in the generation of neuropathic pain.免疫系统在神经性疼痛产生中的作用。
Lancet Neurol. 2012 Jul;11(7):629-42. doi: 10.1016/S1474-4422(12)70134-5.
9
Quantitative Real-Time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects.定量实时PCR检测健康和低敏受试者人白细胞中TRPV1-4基因的表达。
Mol Pain. 2008 Nov 4;4:51. doi: 10.1186/1744-8069-4-51.
10
Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4).与神经或躯体损伤相关的疼痛综合征比较及新型神经性疼痛诊断问卷（DN4）的编制
Pain. 2005 Mar;114(1-2):29-36. doi: 10.1016/j.pain.2004.12.010. Epub 2005 Jan 26.
Zotero 插件