Talebian Ahmad, Soltani Babak, Banafshe Hamid Reza, Moosavi Gholam Abbas, Talebian Motahhareh, Soltani Siamak
M.D., Pediatric Neurologist, Professor, Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Electron Physician. 2018 Feb 25;10(2):6279-6285. doi: 10.19082/6279. eCollection 2018 Feb.
Riboflavin may have an acceptable effect on migraine among children. This study was carried out to determine the prophylactic effect of riboflavin on migraine in children.
This randomized clinical trial study was performed at Shahid Beheshti Hospital in Kashan, Iran from December 2012 to February 2015. Ninety children with migraine were allocated randomly into 3 groups (placebo, low-dose and high-dose riboflavin). The outcomes (frequency, intensity and duration of headaches) were measured at baseline and 12 weeks of medication in each group, and the decrease of them were compared. SPSS software version 16 was used for analysis of the data. Descriptive statistics, Chi-square, Fisher's exact and t-test were used for statistical analyses.
There was a significant decrease of migraine frequency (p=0.000) and mean duration (p=0.000) in the high-dose group compared with the placebo group. No significant reduction of frequency and mean duration of attacks were reported in the low-dose group compared to the placebo group (p=0.49 and p=0.69 respectively). There was no significant reduction of migraine intensity in the low-dose and high-dose groups compared to the placebo group (p=0.71 and p=0.74 respectively).
High-dose riboflavin is a safe, well tolerated, cost-effective method of prophylaxis for children with migraine.
The trial was registered at the Iranian Clinical Trial Registry with number IRCT2013020412361N1.
The study was supported by the Deputy of Research, Kashan University of Medical Sciences (grant number 91073).
核黄素可能对儿童偏头痛有一定疗效。本研究旨在确定核黄素对儿童偏头痛的预防作用。
本随机临床试验于2012年12月至2015年2月在伊朗卡尚的沙希德·贝赫什提医院进行。90名偏头痛儿童被随机分为3组（安慰剂组、低剂量核黄素组和高剂量核黄素组）。在每组用药基线及用药12周时测量结果（头痛频率、强度和持续时间），并比较其下降情况。使用SPSS 16版软件进行数据分析。描述性统计、卡方检验、费舍尔精确检验和t检验用于统计分析。
与安慰剂组相比，高剂量组偏头痛频率（p = 0.000）和平均持续时间（p = 0.000）显著降低。与安慰剂组相比，低剂量组发作频率和平均持续时间无显著降低（分别为p = 0.49和p = 0.69）。与安慰剂组相比，低剂量组和高剂量组偏头痛强度均无显著降低（分别为p = 0.71和p = 0.74）。
高剂量核黄素是预防儿童偏头痛的一种安全、耐受性好且经济有效的方法。
该试验在伊朗临床试验注册中心注册，注册号为IRCT2013020412361N1。
本研究由卡尚医科大学研究副校长资助（资助编号91073）。
