外用美洛昔康与利多卡因联合治疗外阴痛的早期经验。
Early experience with topical meloxicam and lidocaine combination for the treatment of vulvodynia.
作者信息
Kim Rufina, Kelly Kerri-Lynn, Olson Merle, Nickel J Curtis
机构信息
Department of Urology, Queen's University, Kingston, ON, Canada.
Department of Biomedical Engineering, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
出版信息
Can Urol Assoc J. 2018 Aug;12(8):252-255. doi: 10.5489/cuaj.4976. Epub 2018 Apr 6.
INTRODUCTION
We report our early clinical observations on the use of topical meloxicam and lidocaine gel for patients with vulvodynia.
METHODS
This is an early experience in participants with a history of vulvodynia evaluated and treated at the Queen's University Pelvic and Bladder Pain Clinic. Combination meloxicam 0.3% and lidocaine 5% were provided to the participants and they were instructed to apply 5 cc to the vulvar area twice daily. Standardized assessment was conducted for each participant before the start of the topical therapy and again at one week, and included Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), and pain scoring (Likert) for vulvar pain, in addition to a subjective global assessment after a week of treatment.
RESULTS
Of the eight participants, six had a subjective improvement in their symptoms with the use of the combination gel. They reported between one- and four-point reductions on the Likert pain scale and mild to moderate improvement of symptoms. Common side effects reported were burning and stinging.
CONCLUSIONS
The results from this early experience are promising for a potentially effective topical treatment for vulvodynia.
引言
我们报告了外用美洛昔康和利多卡因凝胶治疗外阴痛患者的早期临床观察结果。
方法
这是在女王大学盆腔和膀胱疼痛诊所对有外阴痛病史的参与者进行评估和治疗的早期经验。向参与者提供0.3%美洛昔康和5%利多卡因的组合，指导他们每天两次在外阴区域涂抹5毫升。在局部治疗开始前和一周后对每位参与者进行标准化评估，包括间质性膀胱炎症状指数（ICSI）、间质性膀胱炎问题指数（ICPI）以及外阴疼痛的疼痛评分（李克特量表），此外在治疗一周后进行主观整体评估。
结果
八名参与者中，六名使用组合凝胶后症状有主观改善。他们报告在李克特疼痛量表上疼痛减轻了1至4分，症状有轻度至中度改善。报告的常见副作用是烧灼感和刺痛感。
结论
这一早期经验的结果为外阴痛潜在有效的局部治疗带来了希望。
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