Likar Rudolf, Demschar Susanne, Kager Ingo, Neuwersch Stefan, Pipam Wolfgang, Sittl Reinhard
Department of Anesthesiology and Intensive Care, Hospital Klagenfurt, Klagenfurt, Austria.
Department of Anesthesiology, Interdisciplinary Pain Centre, University Hospital Erlangen, Erlangen, Germany.
Int J Gen Med. 2014 Dec 19;8:9-14. doi: 10.2147/IJGM.S74802. eCollection 2015.
To assess the efficacy and safety of the topical 5% lidocaine medicated plaster in the treatment of localized neuropathic pain.
This was a case series at an Austrian pain clinic, using retrospective analysis.
Data of 27 patients treated for localized neuropathic pain with the 5% lidocaine medicated plaster were retrospectively analyzed. Assessment included changes in overall pain intensity, in intensity of different pain qualities, and of hyperalgesia and allodynia, and changes in sleep quality.
Patients (17 female, ten male; mean age 53.4±11.4 years) presented mainly with dorsalgia (16 patients) or postoperative/posttraumatic pain (seven patients); one patient suffered from both. The mean overall pain intensity prior to treatment with lidocaine medicated plaster was 8.4±1.2 on the 11-point Likert scale. In the majority of cases, the lidocaine plaster was applied concomitantly with preexisting pain medication (81.5% of the patients). During the 6-month observation period, overall mean pain intensity was reduced by almost 5 points (4.98) to 3.5±2.6. Substantial reductions were also observed for neuralgiform pain (5 points from 7.9±2.6 at baseline) and burning pain (3 points from 5.2±4.1). Sleep quality improved from 4.6±2.6 at baseline to 5.5±1.8. Stratification by pain diagnosis showed marked improvements in overall pain intensity for patients with dorsalgia or postoperative/posttraumatic pain. The lidocaine plaster was well tolerated.
Overall, topical treatment with the 5% lidocaine medicated plaster was associated with effective pain relief and was well tolerated.
评估局部用5%利多卡因药用贴剂治疗局限性神经性疼痛的疗效和安全性。
这是奥地利一家疼痛诊所的病例系列研究，采用回顾性分析。
回顾性分析27例使用5%利多卡因药用贴剂治疗局限性神经性疼痛患者的数据。评估包括总体疼痛强度、不同疼痛性质的强度、痛觉过敏和感觉异常的变化，以及睡眠质量的变化。
患者（17例女性，10例男性；平均年龄53.4±11.4岁）主要表现为背痛（16例患者）或术后/创伤后疼痛（7例患者）；1例患者两种疼痛均有。在使用利多卡因药用贴剂治疗前，总体疼痛强度在11点李克特量表上平均为8.4±1.2。在大多数情况下，利多卡因贴剂与现有的止痛药物同时使用（81.5%的患者）。在6个月的观察期内，总体平均疼痛强度降低了近5分（4.98），降至3.5±2.6。神经样疼痛（从基线时的7.9±2.6降低5分）和灼痛（从5.2±4.1降低3分）也有显著降低。睡眠质量从基线时的4.6±2.6改善至5.5±1.8。按疼痛诊断分层显示，背痛或术后/创伤后疼痛患者的总体疼痛强度有显著改善。利多卡因贴剂耐受性良好。
总体而言，局部使用5%利多卡因药用贴剂可有效缓解疼痛，且耐受性良好。
