外阴痛和肛门痛采用 5%巴氯芬和棕榈酸乙醇酰胺局部治疗。
Vulvodynia and proctodynia treated with topical baclofen 5 % and palmitoylethanolamide.
机构信息
Institute for Neuropathic Pain, Spoorlaan 37a, 3735 MV, Bosch en Duin, The Netherlands,
出版信息
Arch Gynecol Obstet. 2014 Aug;290(2):389-93. doi: 10.1007/s00404-014-3218-4. Epub 2014 Apr 2.
BACKGROUND
The prevalence of idiopathic vulvodynia and proctodynia is high. Pain management with anti-depressants and anti-epileptics may induce undesirable side effects. Therefore, topical baclofen cream and palmitoylethanolamide might be new therapeutic options.
CASE
A 33-year-old woman with intractable chronic vulvar and anal pain had to abstain from sexual intercourse and could neither cycle nor sit for more than 5 min. The patient did not respond to standard treatments. We prescribed a combination of topical baclofen 5 % and palmitoylethanolamide 400 mg, three times daily. After 3 months her symptoms decreased more than 50 % and sexual intercourse was possible again without pain.
CONCLUSION
Topical baclofen and palmitoylethanolamide can be a viable treatment option in chronic vulvodynia and proctodynia.
背景
特发性外阴痛和肛门痛的患病率很高。使用抗抑郁药和抗癫痫药进行疼痛管理可能会引起不良副作用。因此，局部应用巴氯芬乳膏和棕榈酸乙酯酰胺可能是新的治疗选择。
病例
一位 33 岁的女性患有难治性慢性外阴和肛门疼痛，以致无法进行性生活，且无法骑自行车或连续坐超过 5 分钟。该患者对标准治疗无反应。我们开出了一种联合局部应用 5%巴氯芬和 400 毫克棕榈酸乙酯酰胺，每日三次。三个月后，她的症状减轻了 50%以上，再次进行性生活时不再感到疼痛。
结论
局部应用巴氯芬和棕榈酸乙酯酰胺可能是慢性外阴痛和肛门痛的可行治疗选择。
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