Chiorescu Stefan, Grad Nicolae Ovidiu, Mironiuc Ion Aurel, Andercou Octavian Aurel
Ann Ital Chir. 2018;89:95-100.
The purpose of the present experimental research was to assess the efficacy of intraperitoneal administration of rosuvastatin in preventing the formation of postoperative peritoneal adhesions.
Peritoneal adhesions were induced in 120 male rats of the Wistar-Bratislava breed, divided into 4 groups (n=30), using a parietal and visceral abrasion model. Group I was designated as the control group; in the case of group II, a saline solution was administered intraperitoneally, while in the case of groups III and IV, rosuvastatin solution with a concentration of 10 mg/kg and 5 mg/kg, respectively, was administered in a single dose, during laparotomy. All rats were sacrificed on the 14th postoperative day and the peritoneal adhesions were assessed macroscopically and microscopically.
The formation of peritoneal adhesions (assessed macroscopically by appreciating their number, the area covered, and the degree of severity) was statistically significantly more reduced in the subjects that received rosuvastatin (groups III and IV) as compared to the control group (p<0.05). The degree of fibrosis assessed microscopically was also statistically significantly reduced in groups III and IV as compared to the control group (p<0.05).
Rosuvastatin administered intraperitoneally correlates with a reduction of peritoneal adhesions in rats.
Rosuvastatin, Peritoneal adhesions, Prevention.
本实验研究的目的是评估腹腔注射瑞舒伐他汀预防术后腹膜粘连形成的疗效。
采用壁层和脏层擦伤模型，在120只Wistar - Bratislava品系雄性大鼠中诱导腹膜粘连，将其分为4组（n = 30）。第一组为对照组；第二组腹腔注射生理盐水，而第三组和第四组在剖腹手术期间分别单次注射浓度为10 mg/kg和5 mg/kg的瑞舒伐他汀溶液。所有大鼠在术后第14天处死，对腹膜粘连进行宏观和微观评估。
与对照组相比，接受瑞舒伐他汀治疗的大鼠（第三组和第四组）腹膜粘连的形成（通过观察粘连数量、覆盖面积和严重程度进行宏观评估）在统计学上显著减少（p < 0.05）。与对照组相比，第三组和第四组微观评估的纤维化程度在统计学上也显著降低（p < 0.05）。
腹腔注射瑞舒伐他汀与大鼠腹膜粘连的减少相关。
瑞舒伐他汀；腹膜粘连；预防
