Giannini A J, Sullivan B, Sarachene J, Loiselle R H
Department of Psychiatry, Northeastern Ohio Universities College of Medicine, Rootstown.
J Clin Psychiatry. 1988 Feb;49(2):62-3.
The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels. All of the women received clonidine and placebo in a double-blind cross-over design that spanned four menstrual cycles. Clonidine was significantly (p less than .05) more effective than placebo in reducing symptoms.
作者研究了可乐定对一组有经前综合征相关症状的女性的影响；该亚组由24名年龄在19至41岁之间的女性组成，她们的β-内啡肽水平有“中度”至“重度”的周期性下降。所有女性均接受可乐定和安慰剂治疗，采用双盲交叉设计，为期四个月经周期。在减轻症状方面，可乐定比安慰剂显著有效（p小于0.05）。
