Detelich Danielle, Markmann James F
Department of Transplantation, Massachusetts General Hospital, Boston, Massachusetts, USA.
Curr Opin Organ Transplant. 2018 Jun;23(3):347-352. doi: 10.1097/MOT.0000000000000531.
Normothermic machine perfusion (NMP) is an emerging technology for liver preservation. Early clinical results demonstrate beneficial effects in reconditioning high-risk grafts. This review discusses the role of normothermic perfusion as a tool to assess graft viability and as a platform for graft intervention and modification.
The potential benefits of NMP extend far beyond organ reconditioning. Recent pilot studies have identified clinically relevant viability criteria, which now require validation in large randomized control trials prior to implementation. Furthermore, preclinical studies demonstrate tremendous potential for NMP as a method to extend the preservation period, thus improving transplant logistics as well as serve as a platform for graft-targeted interventions to optimize the preservation period.
NMP is a multifunctional tool with potential to transform liver preservation and the field of transplantation. Large clinical trials are necessary to optimize perfusion protocols, clarify indications for NMP therapy and justify use as the standard preservation modality.
常温机器灌注（NMP）是一种新兴的肝脏保存技术。早期临床结果表明其对高危移植物的修复具有有益作用。本综述讨论了常温灌注作为评估移植物活力的工具以及作为移植物干预和改良平台的作用。
NMP的潜在益处远远超出器官修复。近期的初步研究已经确定了临床相关的活力标准，在实施之前，这些标准现在需要在大型随机对照试验中进行验证。此外，临床前研究表明NMP作为延长保存期的方法具有巨大潜力，从而改善移植物流，并作为针对移植物的干预平台以优化保存期。
NMP是一种多功能工具，具有改变肝脏保存和移植领域的潜力。需要进行大型临床试验以优化灌注方案，明确NMP治疗的适应症，并证明其作为标准保存方式的合理性。
