Ceresa Carlo D L, Nasralla David, Knight Simon, Friend Peter J
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Curr Opin Organ Transplant. 2017 Jun;22(3):300-305. doi: 10.1097/MOT.0000000000000410.
Preservation of the liver via normothermic machine perfusion (NMP) is rapidly becoming an area of great academic and clinical interest. This review focuses on the benefits and limitations of NMP and where the role for static cold storage may lie.
Clinical studies have recently been published reporting the use of NMP in liver preservation for transplantation. They have described the technology to be well tolerated and feasible with potentially improved posttransplant outcomes. NMP facilitates extended preservation times as well as the potential to increase organ utilization through viability assessment and regeneration. However, this technology is considerably more costly than cold storage and carries significant logistical challenges. Cold storage remains the gold standard preservation for standard criteria livers with good long-term patient and graft survival.
NMP is an exciting new technological advancement in liver preservation, which is likely to have a positive impact in liver transplantation. However, randomized controlled trials are required to justify its inclusion into standard practice and provide evidence to support its efficacy.
通过常温机器灌注（NMP）来保存肝脏正迅速成为一个备受学术界和临床关注的领域。本综述聚焦于NMP的益处和局限性，以及静态冷藏的作用所在。
近期发表的临床研究报告了NMP在肝脏移植保存中的应用。这些研究称该技术耐受性良好且可行，移植后结果可能得到改善。NMP有助于延长保存时间，以及通过活力评估和再生来提高器官利用率。然而，这项技术的成本比冷藏高得多，并且存在重大的后勤挑战。对于符合标准标准的肝脏，冷藏仍然是长期患者和移植物存活良好的金标准保存方法。
NMP是肝脏保存领域一项令人兴奋的新技术进展，可能会对肝移植产生积极影响。然而，需要进行随机对照试验，以证明将其纳入标准实践的合理性，并提供支持其疗效的证据。
