Department of Radiology, LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.
Eur Rev Med Pharmacol Sci. 2018 Mar;22(6):1595-1601. doi: 10.26355/eurrev_201803_14564.
This study intended to explore the efficacy of computed tomography (CT)-guided implantation of iodine-125 (125I) seeds in the treatment of refractory malignant tumors with cancer pain and its influence on tumor markers in the serum.
76 patients with refractory malignant tumors accompanied by cancer pain that received treatments in LongHua Hospital Shanghai University of Traditional Chinese Medicine from September 2013 to August 2014 were selected. They were divided into control group and observation group using a random number table (38 patients in each group). Patients in the control group received simple chemotherapy, while those in the observation group undergone CT-guided implantation of 125I seeds in combination with chemotherapy. Recent efficacy and 1-3-year survival rate were compared between the two groups of patients. The degree of pain relief after treatment was also compared between the two groups of patients. Electrochemiluminescence method was used to detect the concentrations of carcinoembryonic antigen (CEA), sugar chain antigen 199 (CA 199), sugar chain antigen 125 (CA 125), neuron-specific enolase (NSE) and cytokeratin-19-fragment (CYFRA21-1) in the two groups of patients before treatment, and 3 days, 7 days and 30 days after treatment.
Recent disease control rate of the patients in the observation group was higher than that of the patients in the control group (p<0.05). The 1-3-year survival rate after surgery in the observation group was significantly higher than that in the control group (p<0.05). The total efficiency of pain control in the observation group was significantly higher than that in the control group (p<0.05). The levels of tumor markers in the two groups of patients were significantly decreased after treatment, while the reduction in the observation group was more evident than that in the control group (p<0.05).
Our results showed that CT-guided implantation of 125I seeds is effective for the treatment of patients with refractory malignant tumors accompanied by cancer pain. It can reduce the levels of tumor markers, improve the survival rate and prolong the survival time of the patients.
本研究旨在探讨 CT 引导下植入碘-125（125I）种子治疗伴有癌痛的难治性恶性肿瘤的疗效及其对血清肿瘤标志物的影响。
选取 2013 年 9 月至 2014 年 8 月在上海中医药大学附属龙华医院接受治疗的 76 例伴有癌痛的难治性恶性肿瘤患者，采用随机数字表法分为对照组和观察组（每组 38 例）。对照组患者接受单纯化疗，观察组患者接受 CT 引导下 125I 种子植入联合化疗。比较两组患者近期疗效和 1-3 年生存率，比较两组患者治疗后疼痛缓解程度。采用电化学发光法检测两组患者治疗前、治疗后 3 天、7 天和 30 天癌胚抗原（CEA）、糖链抗原 199（CA199）、糖链抗原 125（CA125）、神经元特异性烯醇化酶（NSE）和细胞角蛋白 19 片段（CYFRA21-1）的浓度。
观察组患者近期疾病控制率高于对照组（p<0.05）。观察组患者术后 1-3 年生存率明显高于对照组（p<0.05）。观察组患者疼痛控制总有效率明显高于对照组（p<0.05）。两组患者治疗后肿瘤标志物水平均明显下降，观察组下降幅度明显大于对照组（p<0.05）。
CT 引导下植入 125I 种子治疗伴有癌痛的难治性恶性肿瘤疗效确切，可降低肿瘤标志物水平，提高患者生存率，延长患者生存时间。
