Gao Zhen, Yu Huimin, Di Xuemin, Zhao Jinxin, Liang Yansong, Liu Zezhou, Wang Juan, Zhang Hongtao
Department of Oncology, The Hebei General Hospital, Shijiazhuang, China.
Front Oncol. 2022 Aug 1;12:884491. doi: 10.3389/fonc.2022.884491. eCollection 2022.
Solitary fibrous tumor (SFT) is a rare spindle cell tumor, benign or low-grade malignant, with an extremely low possibility of occurrence of malignant solitary fibrous tumor (MSFT). Surgery is an effective way for treating SFT, but it is often difficult to resect completely due to a large size, with a high recurrence rate and mortality rate after operation. Additionally, SFT is relatively resistant to chemotherapy, and there is a lack of effective systemic drug treatment. These lead to certain difficulties in the treatment of SFT. We report a case of a rare MSFT in the pelvic cavity. With a history of recurrence after two surgeries, this patient underwent surgical removal combined with I seed implantation at our hospital in the context that the tumor could not be completely removed because it was large and adhered to surrounding tissues; after up to 43 months of progression-free survival (PFS), the patient underwent I seed implantation alone, and achieved a complete remission, with a PFS up to 35 months. I seed implantation can be a safe and effective treatment option for unresectable MSFT as well as a potential solution to repeated local recurrence.
孤立性纤维瘤（SFT）是一种罕见的梭形细胞肿瘤，可为良性或低度恶性，恶性孤立性纤维瘤（MSFT）的发生可能性极低。手术是治疗SFT的有效方法，但由于肿瘤体积大，往往难以完全切除，术后复发率和死亡率较高。此外，SFT对化疗相对耐药，且缺乏有效的全身药物治疗。这些导致SFT的治疗存在一定困难。我们报告一例盆腔罕见的MSFT病例。该患者经历了两次手术后复发，因肿瘤体积大且与周围组织粘连无法完全切除，在我院接受了手术切除联合碘粒子植入治疗；在长达43个月的无进展生存期（PFS）后，患者单独接受碘粒子植入治疗，并实现了完全缓解，PFS长达35个月。碘粒子植入对于无法切除的MSFT可能是一种安全有效的治疗选择，也是反复局部复发的潜在解决方案。
