[Preventive effects of curcumin and resveratrol in Alzheimer’s disease].

Demographic study of the last years clearly indicates the tendency of population aging, particularly in Europe. It can lead to an increased risk of diseases typical for old-age, including neurodegenerative diseases, among others Alzheimer’s disease (AD). Thus, the prevention of these diseases presents a major challenge for global public health. The development of AD is mainly attributed to environmental factors, in particular: diet, smoking, cardiovascular diseases, type 2 diabetes and serious cranio-cerebral injuries. The dominant theory of the AD development is amyloid cascade hypothesis, but at the same time, important in the etiology of this disease is the overphosphorylation of tau protein. Despite many years of research, so far, there are no drugs that allow for effective therapy, hence the ongoing intensive exploration of natural substances that can prevent the AD development. Bioactive components of plant origin have recently received considerable attention, because they are relatively safe and cheap due to the wide availability, and quite promising in this group are curcumin and resveratrol.