Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Sport Training and Monitoring, College of Health Science, Wuhan Sports University, Wuhan 430079, China.
Nutrients. 2017 Aug 24;9(9):927. doi: 10.3390/nu9090927.
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders over the age of 65 years old. Although several underlying mechanisms for explaining the pathogenesis of AD are elucidated, the effective supplements or drugs for the intervention of AD are still limited. Recently, impaired autophagy associated with miRNA dysfunction has been reported to involve in aging and aging-related neurodegenerative diseases. Thus, the activation of autophagy through effectively regulating miRNAs may become a potential target for the prevention or treatment of AD. Mounting evidence from in vitro and in vivo AD models has demonstrated that resveratrol, one of polyphenolic compounds, can exert neuroprotective role in neurodegenerative diseases especially AD. In this review, the regulation of miRNAs and autophagy using resveratrol during the prevention and treatment of AD are systematically discussed, which will be beneficial to establish a target for the direct link between pharmacological intervention and AD in the future.
阿尔茨海默病（AD）是 65 岁以上人群中最常见的神经退行性疾病之一。尽管已经阐明了几种解释 AD 发病机制的潜在机制，但用于 AD 干预的有效补充剂或药物仍然有限。最近，与 miRNA 功能障碍相关的自噬受损已被报道与衰老和与衰老相关的神经退行性疾病有关。因此，通过有效调节 miRNA 激活自噬可能成为预防或治疗 AD 的潜在靶点。来自体外和体内 AD 模型的越来越多的证据表明，白藜芦醇作为多酚化合物之一，在神经退行性疾病，特别是 AD 中具有神经保护作用。在本综述中，系统讨论了使用白藜芦醇调节 miRNA 和自噬在 AD 的预防和治疗中的作用，这将有助于为未来药物干预与 AD 之间的直接联系建立一个靶点。
