Melanosis Coli

Melanosis coli is a condition associated with lipofuscin deposition (not melanin as the name might imply, and hence, alternatively termed "pseudomelanosis") in the lamina propria of the large intestines. This phenomenon was first described by Andral and Cruveilhier in 1830. Historically, laxatives, primarily from plant-based anthraquinones (ie, senna, rhubarb, cascara, and aloe), are the main culprits. As these laxative supplements pass through the colon, they become active and cause cell death and apoptosis in the lining of the colon, eventually causing dark pigmentation of the colon (see .  Melanosis Coli). Diagnosis is typically made by colonoscopy. Discontinuing laxative use usually leads to the resolution of melanosis coli. Melanosis coli is not associated with an increased risk of colon cancer.